Jang Insan, Shim Seong-Cheol, Choi Dong-Soon, Cha Bong-Kuen, Lee Jae-Kwan, Choe Byung-Hak, Choi Won-Youl
Department of Orthodontics, College of Dentistry, Gangneung-Wonju National University, Gangneung, 210-720, South Korea.
Biomed Microdevices. 2015 Aug;17(4):76. doi: 10.1007/s10544-015-9986-1.
To increase the stability of orthodontic miniscrews, TiO2 nanotube arrays were fabricated on the surface of Ti miniscrews and the effect of those arrays on the osseointegration of miniscrews was evaluated. Highly ordered TiO2 nanotube arrays were grown on the surface of orthodontic miniscrews. Ethylene glycol based electrolyte was used in the anodic oxidation process. Two-step anodic oxidation was conducted to obtain clean and open windows in TiO2 nanotube arrays. The diameter and length of the TiO2 nanotube arrays were ~ 70 nm and ~ 5 μm, respectively. The miniscrews with TiO2 nanotube arrays were implanted in the legs of New Zealand white rabbits for 8 weeks. Histological osseointegration was assessed by bone-to-implant contact ratio, and three-dimensional bone volume ratio was measured by micro-computed tomography analysis. The miniscrews with TiO2 nanotube arrays had a greater mean bone-to-implant contact ratio of 52.8 % than the control, 29.3 %. Mean bone volume ratio (BV/TV) was also higher in the miniscrews with TiO2 nanotube arrays, at 81.2 % than those in the control via micro-CT analysis. Our findings support that TiO2 nanotube arrays on the surface of miniscrews enhance osseointegration and improve the stability of the miniscrew.
为提高正畸微螺钉的稳定性，在钛微螺钉表面制备了二氧化钛纳米管阵列，并评估了这些阵列对微螺钉骨整合的影响。在正畸微螺钉表面生长出高度有序的二氧化钛纳米管阵列。阳极氧化过程中使用了基于乙二醇的电解液。进行两步阳极氧化以在二氧化钛纳米管阵列中获得清洁且开放的窗口。二氧化钛纳米管阵列的直径和长度分别约为70纳米和约5微米。将带有二氧化钛纳米管阵列的微螺钉植入新西兰白兔的腿部8周。通过骨与种植体接触率评估组织学骨整合情况，并通过显微计算机断层扫描分析测量三维骨体积比。带有二氧化钛纳米管阵列的微螺钉的平均骨与种植体接触率为52.8%，高于对照组的29.3%。通过显微CT分析，带有二氧化钛纳米管阵列的微螺钉的平均骨体积比（BV/TV）也更高，为81.2%，高于对照组。我们的研究结果支持微螺钉表面的二氧化钛纳米管阵列可增强骨整合并提高微螺钉的稳定性。
