Attama Anthony A, Umeyor Chukwuebuka E
Drug Delivery & Nanomedicines Research Unit, Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka 410001, Enugu State, Nigeria.
Nanomedicine & Drug Delivery Research Unit, Department of Pharmaceutics & Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Nnamdi Azikiwe University, Awka 422001, Anambra State, Nigeria.
Ther Deliv. 2015;6(6):669-84. doi: 10.4155/tde.15.23.
Novel solid lipid drug delivery systems such as solid lipid nanoparticles (SLN) have attracted wide and increasing attention in recent years. It has been sought as an interesting alternative drug delivery carrier system for bioactives for a variety of delivery routes. They show major advantages such as sustained release, improved bioavailability, improved drug incorporation and very wide application. This paper presents a discussion on the production protocols of SLN, lyophilization of SLN and delivery of SLN across the blood-brain barrier. Special attention was also paid to entrapment and release of drugs from SLN and strategies to enhance drug entrapment in SLN for sustained release. Analytical methods for the characterization of SLN were also discussed. Various routes of administration of SLN were presented as well as a consideration of the ethical issues and future prospects in the production and use of SLN for sustained release of bioactives.
近年来，新型固体脂质药物递送系统，如固体脂质纳米粒（SLN），已引起广泛且日益增长的关注。它已被视作一种用于多种给药途径的生物活性物质的有趣替代药物递送载体系统。它们具有诸如缓释、提高生物利用度、改善药物包封率以及广泛应用等主要优点。本文讨论了固体脂质纳米粒的制备方案、固体脂质纳米粒的冻干以及固体脂质纳米粒跨越血脑屏障的递送。还特别关注了药物从固体脂质纳米粒中的包封和释放，以及增强药物在固体脂质纳米粒中包封以实现缓释的策略。还讨论了用于表征固体脂质纳米粒的分析方法。介绍了固体脂质纳米粒的各种给药途径，并考虑了在生产和使用固体脂质纳米粒以实现生物活性物质缓释方面的伦理问题和未来前景。
