Codrea Cosmin Iulian, Fruth Victor
Department of Oxide Compounds and Materials Science, Institute of Physical Chemistry "Ilie Murgulescu" of the Romanian Academy, 060021 Bucharest, Romania.
Biomimetics (Basel). 2025 Jul 1;10(7):429. doi: 10.3390/biomimetics10070429.
The increasing incidence of osteoporotic fractures determines ongoing research on new methods and strategies for improving the difficult healing process of this type of fracture. Osteoporotic patients suffer from the intense side effects of accustomed drug treatment and its systemic distribution in the body. To overcome these drawbacks, besides searching for new drugs, 3D-printed scaffolds and drug delivery systems have started to be increasingly seen as the main strategy employed against osteoporosis. Three-dimensionally printed scaffolds can be tailored in intricate designs and make use of nanoscale topographical and biochemical cues able to enhance bone tissue regeneration. Research regarding drug delivery systems is exploring bold new ways of targeting bone tissue, making use of designs involving nanoparticles and intricate encapsulation and support methods. The local administration of treatment with the help of a scaffold-based drug delivery system looks like the best option through its use of the advantages of both structures. Biomimetic systems are considered the future norm in the field, while stimuli-responsiveness opens the door for the next level of efficiency, patient compliance, and a drastic reduction in side effects. The successful approval of these products still requires numerous challenges throughout the development and regulatory processes, but the interest and effort in this direction are high. This review explored various strategies for managing osteoporosis, emphasizing the use of scaffolds for targeted drug delivery to bone tissue. Instead of covering the whole subject, we focused on the most important aspects, with the intention to provide an up-to-date and useful introduction to the management of osteoporosis.
骨质疏松性骨折发病率的不断上升，促使人们持续开展研究，探索新的方法和策略，以改善这类骨折愈合困难的状况。骨质疏松患者承受着常规药物治疗的强烈副作用及其在体内的全身分布影响。为克服这些缺点，除了寻找新药之外，3D打印支架和药物递送系统已开始越来越多地被视为对抗骨质疏松症的主要策略。三维打印支架可以设计成复杂的形状，并利用纳米级的地形和生化线索来促进骨组织再生。关于药物递送系统的研究正在探索大胆的新方法来靶向骨组织，利用涉及纳米颗粒以及复杂的封装和支撑方法的设计。借助基于支架的药物递送系统进行局部治疗似乎是最佳选择，因为它兼具了两种结构的优势。仿生系统被认为是该领域未来的标准，而刺激响应性为提高效率、患者依从性以及大幅减少副作用打开了新的大门。这些产品要成功获批，在整个开发和监管过程中仍面临诸多挑战，但人们在这方面的兴趣和努力很高。本综述探讨了治疗骨质疏松症的各种策略，重点强调了使用支架向骨组织进行靶向药物递送。我们没有涵盖整个主题，而是聚焦于最重要的方面，旨在为骨质疏松症的治疗提供最新且实用的介绍。
