全血中未衍生化茶碱的快速气相色谱测定法
Rapid gas chromatographic determination of underivatized theophylline in whole blood.
作者信息
Sheehan M, Haythorn P
出版信息
J Chromatogr. 1976 Feb 18;117(2):392-8. doi: 10.1016/0021-9673(76)80016-7.
PMID:2615
Abstract
A rapid gas chromatographic method for the determination of underivatized theophylline in whole blood is described. Theophylline is extracted from acidified blood and chromatographed directly using cyheptamide as an internal standard. Concentrations of the drug down to 2 mug/ml in blood could be determined with recoveries ranging from 90 to 110%.
摘要
本文描述了一种快速气相色谱法，用于测定全血中未衍生化的茶碱。从酸化血液中提取茶碱，并直接以环庚胺为内标进行色谱分析。血液中低至2微克/毫升的药物浓度可以测定，回收率在90%至110%之间。
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