Klimová Z, Hojerová J, Beránková M
Laboratories of Cosmetology, Faculty of Chemical and Food Technology, Slovak University of Technology, Radlinského 9, Bratislava, Slovak Republic.
Food Chem Toxicol. 2015 Sep;83:237-50. doi: 10.1016/j.fct.2015.06.025. Epub 2015 Jul 4.
Due to health concerns about safety, three UV-filters (Benzophenone-3, BP3, 10%; Ethylhexyl Methoxycinnamate, EHMC, 10%; Butyl Methoxydibenzoylmethane, BMDBM; 5%) were examined in vitro for absorption on full-thickness pig-ear skin, mimicking human in-use conditions. Kinetic profiles confirmed the rapid permeation of BP3; after the first hour of skin (frozen-stored) exposure to 2 mg/cm(2) (W/O sunscreen; recommended but unrealistic amount), about 0.5% of the applied dose passed into the receptor fluid. The absorption rate of filters was higher from W/O than from O/W emulsions. The fresh/frozen-stored skin permeability coefficient (0.83-0.54) for each UV filter was taken into account. Systemic Exposure Dosage of BP3, EHMC, BMDBM for humans as a consequence of (i) whole-body and (ii) face treatment with 0.5 mg/cm(2) of W/O sunscreen for 6-h skin exposure followed by washing and subsequent 18-h permeation (a realistic scenario) were estimated to be (i) 4744, 1032 and 1036 μg/kg-bw/day, and (ii) 153, 33 and 34 μg/kg-bw/day, respectively. From Margin of Safety for BP3, EHMC and BMDBM (i) 42, 485 and 192 as well as (ii) 1307; 15,151 and 5882, respectively, only the value of 42 (<100) for BP3 indicated a possible health risk. Escalation of a phobia towards all organic UV filters is undesirable.
出于对安全性的健康担忧，研究人员在体外对三种紫外线过滤剂（二苯甲酰甲烷，BP3，10%；甲氧基肉桂酸乙基己酯，EHMC，10%；二乙氨羟苯甲酰基苯甲酸己酯，BMDBM，5%）在全层猪耳皮肤上的吸收情况进行了检测，模拟人体实际使用条件。动力学曲线证实了BP3的快速渗透；在将皮肤（冷冻保存）暴露于2mg/cm²（不含防晒剂；推荐但不切实际的用量）一小时后，约0.5%的施用剂量进入了受体液。过滤剂从不含水的乳剂中的吸收率高于从水包油型乳剂中的吸收率。考虑到每种紫外线过滤剂的新鲜/冷冻保存皮肤渗透系数（0.83 - 0.54）。对人体因（i）全身和（ii）面部使用0.5mg/cm²不含水的防晒剂进行6小时皮肤暴露，随后清洗并进行18小时渗透（实际情况）而导致的BP3、EHMC、BMDBM的全身暴露剂量进行了估算，结果分别为（i）4744、1032和1036μg/kg体重/天，以及（ii）153、33和34μg/kg体重/天。从BP3、EHMC和BMDBM的安全系数来看，（i）分别为42、485和192，以及（ii）分别为1307、15151和5882，只有BP3的42（<100）值表明可能存在健康风险。对所有有机紫外线过滤剂产生恐惧升级是不可取的。
