Yapca O E, Delibas I B, Karaca I, Kumtepe Y, Kadanali S
Clin Exp Obstet Gynecol. 2015;42(3):311-4.
To evaluate time-limited hydrotubation combined with clomiphene citrate as treatment for unexplained infertility.
In this unblinded, randomized controlled trial of patients who had unexplained infertility, 40 patients were treated with time-limited hydrotubation (saline, 20 ml; flushed within 20 to 30 seconds) and clomphene citrate (total, 70 cycles) and 40 patients were treated with clomiphene citrate alone (total, 74 cycles). All women underwent an ovulation induction protocol with clomiphene citrate (100 mg/d orally for five days, from day 3 to day 7 of the cycle). Hydrotubation was performed after detection of the dominant follicle.
There were 15 pregnancies in the 80 patients (19%) (total, 144 stimulated cycles; 10% pregnancies per cycle). The frequency of clinical pregnancy per cycle was significantly greater in patients who were treated with hydrotubation and clomiphene citrate (nine pregnancies per cycle [13%]) than those treated with clomiphene citrate alone (two pregnancies per cycle [3%]; odds ratio, 5.3; 95% confidence interval, 1.1 to 25.5; p ≤ 0.05). The frequency of pregnancy per patient (total, clinical, or chemical) was similar for the two treatment groups. The frequency of live birth or abortion per cycle or patient was similar between the two treatment groups.
Time-limited hydrotubation and clomiphene citrate may increase the frequency of clinical pregnancy per cycle in women who have unexplained infertility.
评估限时输卵管通液联合枸橼酸氯米芬治疗不明原因不孕症的效果。
在这项针对不明原因不孕症患者的非盲、随机对照试验中，40例患者接受限时输卵管通液（生理盐水20 ml，在20至30秒内冲洗）及枸橼酸氯米芬治疗（共70个周期），40例患者仅接受枸橼酸氯米芬治疗（共74个周期）。所有女性均采用枸橼酸氯米芬进行促排卵方案（周期第3至7天，口服100 mg/d，共5天）。在检测到优势卵泡后进行输卵管通液。
80例患者中有15例妊娠（19%）（共144个促排卵周期，每个周期妊娠率为10%）。接受输卵管通液和枸橼酸氯米芬治疗的患者每个周期的临床妊娠率（每个周期9例妊娠[13%]）显著高于仅接受枸橼酸氯米芬治疗的患者（每个周期2例妊娠[3%]；优势比为5.3；95%置信区间为1.1至25.5；p≤0.05）。两个治疗组患者的妊娠率（包括临床妊娠或化学妊娠）相似。两个治疗组每个周期或每位患者的活产或流产率相似。
限时输卵管通液和枸橼酸氯米芬可能会提高不明原因不孕症女性每个周期的临床妊娠率。
