Department of Pathology and Immunology; University of Geneva Medical School ; Geneva, Switzerland.
Oncoimmunology. 2015 May 8;4(5):e988476. doi: 10.4161/2162402X.2014.988476. eCollection 2015 May.
Plasmacytoid dendritic cells (pDCs) are not only potent inflammatory cytokine producers but also function as antigen-presenting cells (APCs). We have shown that vaccination using CpG-B activated tumor antigen (Ag) presenting pDCs induce Th17 cells that promote intratumoral immune cell recruitment, including antitumor cytotoxic T lymphocytes CTLs. Therefore, strategies targeting both innate and adaptive pDC functions may improve antitumor T-cell immunity.
浆细胞样树突状细胞（pDCs）不仅是强有力的炎症细胞因子产生细胞，而且还作为抗原呈递细胞（APCs）发挥作用。我们已经表明，使用 CpG-B 激活的肿瘤抗原（Ag）呈递 pDC 进行疫苗接种可诱导 Th17 细胞，促进肿瘤内免疫细胞募集，包括抗肿瘤细胞毒性 T 淋巴细胞（CTLs）。因此，针对先天和适应性 pDC 功能的策略可能会改善抗肿瘤 T 细胞免疫。
