[克拉斯诺亚尔斯克地区分离出的沙门氏菌属的抗生素耐药性]

[ANTIBIOTIC RESISTANCE OF SALMONELLA SPP. ISOLATED IN THE TERRITORY OF THE KRASNOIARSK REGION].

作者信息

Reshetneva I T, Per'ianova O V, Dmitrieva G M, Ostapova T S

出版信息

Gig Sanit. 2015 Mar-Apr;94(2):35-8.

Abstract

There were studied Salmonella spp. isolated from various objects (sick patients, bacteria carriers, food, sewages) in the Krasnoyarsk region. Susceptibility to antimicrobial drugs was estimated with disc diffusion method. Bacterial cultures form sick patients were highly susceptible to aminoglycosides (amikacin and gentamicin)--susceptible strains accounted for 98-99%, carbapenems (imipenem)--100%, cephalosporins (cephtriaxone)--97.8%, fluoroquinolones (ophloxacin)--95.8%, quinolones (ciprofloxacin)-- 88.9%, chloramphenicol--86.8%. Salmonella showed lesser susceptibility to sulphamethoxazole/trimethoprim 81.4%. Ampicillin--73.6% inhibitor protected antibiotic amoxicillin/clavulanic acid--86.4%. Salmonella spp. are the most resistant to tetracycline, the proportion of susceptible strains was less than a third--22.1%. The comparison of resistance of serovar S. enterica Enteritidis. with other serologic strains 'of S. enterica (S. Typhimurium, S. Infantis, S. Tshiongtve, S. Agama et al.) revealed greater resistance of anot Eneteritidis)) isolates to ampicillin, amoxicillin/ clavulanic acid,. ciprofloxacin and greater differences in resistance were to ofloksacin and, co-trimoxasol. The most high resistance ofthe all serovars S. enterica is to tetracycline (S. Enteritidis--26.2%, "non Enteritidis"--9.1%). Thus salmonella circulating in the Krasnoyarsk region are characterized by susceptibility to the most of antimicrobial drugs. The high resistance of islitates is revealed to tetracycline, ampicillin and sulfonamides.

摘要

对从克拉斯诺亚尔斯克地区的各种物体（患病患者、带菌者、食物、污水）中分离出的沙门氏菌属进行了研究。采用纸片扩散法评估其对抗菌药物的敏感性。来自患病患者的细菌培养物对氨基糖苷类（阿米卡星和庆大霉素）高度敏感——敏感菌株占98 - 99%，碳青霉烯类（亚胺培南）——100%，头孢菌素类（头孢曲松）——97.8%，氟喹诺酮类（氧氟沙星）——95.8%，喹诺酮类（环丙沙星）——88.9%，氯霉素——86.8%。沙门氏菌对磺胺甲恶唑/甲氧苄啶的敏感性较低，为81.4%。氨苄西林——73.6%，抑制剂保护型抗生素阿莫西林/克拉维酸——86.4%。沙门氏菌属对四环素的耐药性最强，敏感菌株的比例不到三分之一——22.1%。肠炎沙门氏菌血清型与肠炎沙门氏菌其他血清学菌株（鼠伤寒沙门氏菌、婴儿沙门氏菌、茨昂韦沙门氏菌、阿加马沙门氏菌等）的耐药性比较显示，肠炎沙门氏菌分离株对氨苄西林、阿莫西林/克拉维酸、环丙沙星的耐药性更强，对氧氟沙星和复方新诺明的耐药性差异更大。所有肠炎沙门氏菌血清型中对四环素的耐药性最高（肠炎沙门氏菌——26.2%，“非肠炎沙门氏菌”——9.1%）。因此，在克拉斯诺亚尔斯克地区传播的沙门氏菌对大多数抗菌药物敏感。分离株对四环素、氨苄西林和磺胺类药物表现出高耐药性。