Zhang Yin, Lavigne Guy, César Vincent
†CNRS, LCC (laboratoire de Chimie de Coordination), 205 route de Narbonne, F-31077 Toulouse Cedex 4, France.
‡Université de Toulouse, UPS, INPT, 31077 Toulouse, France.
J Org Chem. 2015 Aug 7;80(15):7666-73. doi: 10.1021/acs.joc.5b01272. Epub 2015 Jul 17.
The cross-coupling of aryl tosylates with amines and anilines was achieved by using for the first time a Pd-NHC system based on the popular Pd-PEPPSI precatalyst platform in which the anchoring imidazol-2-ylidene ligand IPr((NMe2)2) incorporates two dimethylamino groups as backbone substituents enhancing both the electronic and steric properties of the carbene. The system optimization and its application scope are disclosed.
首次使用基于流行的Pd-PEPPSI预催化剂平台的Pd-NHC体系实现了芳基甲苯磺酸酯与胺类及苯胺的交叉偶联。在该体系中，锚定的咪唑-2-亚基配体IPr((NMe2)2)含有两个作为主链取代基的二甲氨基，增强了卡宾的电子和空间性质。本文还披露了该体系的优化及其应用范围。
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