Stratingh Institute for Chemistry, University of Groningen , Nijenborgh 4, 9747 AG Groningen, The Netherlands.
Chem Rev. 2018 Jan 24;118(2):614-678. doi: 10.1021/acs.chemrev.7b00588. Epub 2018 Jan 16.
Lignin, a major component of lignocellulose, is the largest source of aromatic building blocks on the planet and harbors great potential to serve as starting material for the production of biobased products. Despite the initial challenges associated with the robust and irregular structure of lignin, the valorization of this intriguing aromatic biopolymer has come a long way: recently, many creative strategies emerged that deliver defined products via catalytic or biocatalytic depolymerization in good yields. The purpose of this review is to provide insight into these novel approaches and the potential application of such emerging new structures for the synthesis of biobased polymers or pharmacologically active molecules. Existing strategies for functionalization or defunctionalization of lignin-based compounds are also summarized. Following the whole value chain from raw lignocellulose through depolymerization to application whenever possible, specific lignin-based compounds emerge that could be in the future considered as potential lignin-derived platform chemicals.
木质素是木质纤维素的主要成分，是地球上最大的芳香族建筑砌块来源，具有作为生物基产品生产原料的巨大潜力。尽管木质素结构坚固且不规则，最初存在一些挑战，但这种引人入胜的芳香族生物聚合物的利用已经取得了长足的进步：最近，许多有创意的策略通过催化或生物催化解聚以高收率提供了明确的产品。本综述的目的是深入了解这些新方法以及这些新兴结构在合成生物基聚合物或具有药理活性的分子方面的潜在应用。综述还总结了木质素基化合物的功能化或去功能化的现有策略。沿着从原始木质纤维素通过解聚到应用的整个价值链，尽可能地出现了特定的木质素基化合物，它们将来可能被视为有潜力的木质素衍生平台化学品。
