Jia Jemianne Bautista, Lall Chandana, Tirkes Temel, Gulati Rajesh, Lamba Ramit, Goodwin Scott C
Department of Radiology, University of California, Irvine School of Medicine, 101 The City Drive South, Mail Code: 5005, Orange, CA, 92868, USA,
Insights Imaging. 2015 Aug;6(4):479-87. doi: 10.1007/s13244-015-0417-x. Epub 2015 Jul 11.
Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. The agents most commonly associated with chemotherapy-associated nephrotoxicity are methotrexate, semustine, streptozocin, mithramycin, and cisplatin. Certain chemotherapeutic agents have adverse effects on the kidneys and urothelium that can be visualized radiographically, including cystic change, interstitial nephritis, papillary necrosis, urothelial changes, haemorrhagic cystitis, acute tubular necrosis, and infarction. This review focuses on imaging features identifying complications of chemotherapy in the kidneys and collecting system and provides didactic cases to alert referring clinicians.
• Nephrotoxicity is a common adverse effect of many chemotherapeutic agents. • Chemotherapies have adverse renal and urothelial effects that can be visualized radiographically. • Crizotinib use can result in the development of complex renal cysts.
肾毒性是许多化疗药物常见的不良反应。与化疗相关肾毒性最常关联的药物是甲氨蝶呤、司莫司汀、链脲佐菌素、光辉霉素和顺铂。某些化疗药物对肾脏和尿路上皮有不良影响，可通过影像学观察到，包括囊性改变、间质性肾炎、乳头坏死、尿路上皮改变、出血性膀胱炎、急性肾小管坏死和梗死。本综述重点关注识别肾脏和集合系统化疗并发症的影像学特征，并提供典型病例以提醒转诊的临床医生。
• 肾毒性是许多化疗药物常见的不良反应。• 化疗对肾脏和尿路上皮有不良影响，可通过影像学观察到。• 使用克唑替尼可导致复杂性肾囊肿的形成。
