Mehde Atheer Awad, Yusof Faridah, Adel Mehdi Wesen, Zainulabdeen Jwan Abdulmohsin
Department of Biotechnology , College of Engineering, International Islamic University Malaysia, Kuala Lumpur, Malaysia E-mail :
Asian Pac J Cancer Prev. 2015;16(12):5059-62. doi: 10.7314/apjcp.2015.16.12.5059.
ALL is an irredeemable disease due to the resistance to treatment. There are several influences which are involved in such resistance to chemotherapy, including oxidative stress as a result of the generation of reactive oxygen species (ROS) and presence of hypodiploid cells. Cluster of differentiation 26 (CD26), also known as dipeptidyl peptidase-4, is a 110 kDa, multifunctional, membrane-bound glycoprotein.
The aim of this study was to evaluate the clinical significance of serum CD26 in patients with acute lymphoblastic leukaemia patients in the post remission induction phase, as well as the relationship between CD26 activity and the oxidative stress status.
CD26, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI), in addition to activity of related enzymes myeloperoxidase, glutathione- s-transferase and xanthine oxidase, were analysed in sixty children with acute lymphoblastic leukaemia in the post remission induction phase.
The study showed significant elevation in CD26, TOS and OSI levels in patients with acute lymphoblastic leukaemia in the post remission induction phase in comparison to healthy control samples. In contrast, myeloperoxidase, glutathione-s-transferase and xanthine oxidase activities were decreased significantly. A significant correlation between CD26 concentration and some oxidative stress parameters was evident in ALL patients.
Serum levels of CD26 appear to be useful as a new biomarker of oxidative stress in children with acute lymphoblastic leukaemia in the post remission induction phase, and levels of antioxidants must be regularly estimated during the treatment of children with ALL.
由于对治疗产生耐药性，急性淋巴细胞白血病（ALL）是一种无法治愈的疾病。化疗耐药涉及多种因素，包括活性氧（ROS）生成导致的氧化应激以及亚二倍体细胞的存在。分化簇26（CD26），也称为二肽基肽酶-4，是一种110 kDa的多功能膜结合糖蛋白。
本研究旨在评估缓解诱导期急性淋巴细胞白血病患者血清CD26的临床意义，以及CD26活性与氧化应激状态之间的关系。
对60例缓解诱导期急性淋巴细胞白血病患儿进行了CD26、总抗氧化状态（TAS）、总氧化状态（TOS）、氧化应激指数（OSI）分析，此外还分析了相关酶髓过氧化物酶、谷胱甘肽-S-转移酶和黄嘌呤氧化酶的活性。
研究表明，与健康对照样本相比，缓解诱导期急性淋巴细胞白血病患者的CD26、TOS和OSI水平显著升高。相反，髓过氧化物酶、谷胱甘肽-S-转移酶和黄嘌呤氧化酶的活性显著降低。在ALL患者中，CD26浓度与一些氧化应激参数之间存在显著相关性。
血清CD26水平似乎可作为缓解诱导期急性淋巴细胞白血病患儿氧化应激的新生物标志物，在ALL患儿治疗期间必须定期评估抗氧化剂水平。
