Steele Scott R, Chang George J, Hendren Samantha, Weiser Marty, Irani Jennifer, Buie W Donald, Rafferty Janice F
Prepared by The Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons.
Dis Colon Rectum. 2015 Aug;58(8):713-25. doi: 10.1097/DCR.0000000000000410.
Current evidence suggests improved rates of curative secondary treatment following identification of recurrence among patients who participate in a surveillance program after initial curative resection of colon or rectal cancer. The newer data show that surveillance CEA, chest and liver imaging,and colonoscopy can also improve survival through early diagnosis of recurrence; thus, these modalities are now included in the current guideline. Although the optimum strategy of surveillance for office visits, CEA, chest and liver imaging, and colonoscopy is not yet defined, routine surveillance does improve the detection of recurrence that can be resected with curative intent. Recommended surveillance schedules are shown in Table 4. However, the factors to be considered when recommending surveillance include underlying risk for recurrence, patient comorbidity, and the ability to tolerate major surgery to resect recurrent disease or palliative chemotherapy, performance status, physiologic age, preference, and compliance. The success of surveillance for early detection of curable recurrence will depend on patient and provider involvement to adhere to the surveillance schedule and avoid unnecessary examination. It should be noted that, after curative resection of colorectal cancer, patients are still at risk for other common malignancies(lung, breast, cervix, prostate) for which standard screening recommendations should be observed and measures to maintain general health (risk reduction for cardiovascular disease, eg, cessation of smoking, control of blood pressure and diabetes mellitus, balanced diet, regular exercise and sleep, and flu vaccines) should be recommended.
目前的证据表明,在结肠癌或直肠癌初次根治性切除术后参与监测计划的患者中,复发确诊后进行根治性二次治疗的比例有所提高。最新数据显示,监测癌胚抗原(CEA)、胸部和肝脏影像学检查以及结肠镜检查也可通过早期诊断复发来提高生存率;因此,这些检查方式现已纳入现行指南。尽管针对门诊就诊、CEA、胸部和肝脏影像学检查以及结肠镜检查的最佳监测策略尚未确定,但常规监测确实能提高可进行根治性切除的复发病灶的检出率。推荐的监测时间表见表4。然而,推荐监测时需要考虑的因素包括复发的潜在风险、患者的合并症、耐受切除复发病灶的大手术或姑息化疗的能力、体能状态、生理年龄、偏好和依从性。早期发现可治愈性复发的监测成功与否将取决于患者和医疗服务提供者参与并遵守监测时间表,以及避免不必要的检查。应当指出,结直肠癌根治性切除术后,患者仍有患其他常见恶性肿瘤(肺癌、乳腺癌、宫颈癌、前列腺癌)的风险,对此应遵循标准的筛查建议,并推荐维持总体健康的措施(如降低心血管疾病风险,包括戒烟、控制血压和糖尿病、均衡饮食、定期锻炼和睡眠以及接种流感疫苗)。