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Neuropsychopharmacology. 2014 Nov;39(12):2769-76. doi: 10.1038/npp.2014.125. Epub 2014 May 30.
2
Parametric Imaging and Test-Retest Variability of ¹¹C-(+)-PHNO Binding to D₂/D₃ Dopamine Receptors in Humans on the High-Resolution Research Tomograph PET Scanner.¹¹C-(+)-PHNO与人类D₂/D₃多巴胺受体结合在高分辨率研究型断层PET扫描仪上的参数成像及重测变异性
J Nucl Med. 2014 Jun;55(6):960-6. doi: 10.2967/jnumed.113.132928. Epub 2014 Apr 14.
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Dopamine D₃ receptor alterations in cocaine-dependent humans imaged with [¹¹C](+)PHNO.使用[¹¹C](+)PHNO对可卡因依赖者进行成像时多巴胺D₃受体的改变
Drug Alcohol Depend. 2014 Jun 1;139:100-5. doi: 10.1016/j.drugalcdep.2014.03.013. Epub 2014 Mar 20.
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Changes in dopamine release and dopamine D2/3 receptor levels with the development of mild obesity.随着轻度肥胖的发展，多巴胺释放及多巴胺D2/3受体水平的变化。
Synapse. 2014 Jul;68(7):317-20. doi: 10.1002/syn.21738. Epub 2014 Mar 17.
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In vivo imaging of cerebral dopamine D3 receptors in alcoholism.酒精中毒患者大脑多巴胺D3受体的体内成像
Neuropsychopharmacology. 2014 Jun;39(7):1703-12. doi: 10.1038/npp.2014.18. Epub 2014 Jan 28.
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Imaging nicotine- and amphetamine-induced dopamine release in rhesus monkeys with [(11)C]PHNO vs [(11)C]raclopride PET.用 [(11)C]PHNO 与 [(11)C]raclopride PET 对恒河猴进行成像，研究尼古丁和安非他命诱导的多巴胺释放。
Neuropsychopharmacology. 2014 Mar;39(4):866-74. doi: 10.1038/npp.2013.286. Epub 2013 Oct 15.
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Elevation of dopamine induced by cigarette smoking: novel insights from a [11C]-+-PHNO PET study in humans.吸烟引起的多巴胺升高：来自人类 [11C]-+-PHNO PET 研究的新见解。
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Heightened D3 dopamine receptor levels in cocaine dependence and contributions to the addiction behavioral phenotype: a positron emission tomography study with [11C]-+-PHNO.可卡因依赖中 D3 多巴胺受体水平升高及其对成瘾行为表型的贡献：用 [11C]-+-PHNO 进行的正电子发射断层扫描研究。
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Environmental modulation of drug taking: Nonhuman primate models of cocaine abuse and PET neuroimaging.环境对药物滥用的影响：可卡因滥用的非人灵长类动物模型和 PET 神经影像学。
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使用[(11)C](+)PHNO对健康人和可卡因依赖者进行成像的多巴胺D2/3受体可用性与社会地位的初步研究。

A preliminary study of dopamine D2/3 receptor availability and social status in healthy and cocaine dependent humans imaged with [(11)C](+)PHNO.

作者信息

Matuskey David, Gaiser Edward C, Gallezot Jean-Dominique, Angarita Gustavo A, Pittman Brian, Nabulsi Nabeel, Ropchan Jim, MaCleod Paige, Cosgrove Kelly P, Ding Yu-Shin, Potenza Marc N, Carson Richard E, Malison Robert T

机构信息

Department of Diagnostic Radiology, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale University, New Haven, CT, United States.

Department of Diagnostic Radiology, Yale University, New Haven, CT, United States; Department of Psychiatry, Yale University, New Haven, CT, United States.

出版信息

Drug Alcohol Depend. 2015 Sep 1;154:167-73. doi: 10.1016/j.drugalcdep.2015.06.039. Epub 2015 Jun 30.

DOI:10.1016/j.drugalcdep.2015.06.039
PMID:26164205
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4536182/
Abstract

BACKGROUND

Previous work in healthy non-human primates and humans has shown that social status correlates positively with dopamine 2/3 receptor (D2/3R) availability imaged with antagonist radioligands and positron emission tomography (PET). Further work in non-human primates suggests that this relationship is disrupted by chronic cocaine administration. This exploratory study examined the relationship between social status and D2/3R availability in healthy (HH) and cocaine dependent (CD) humans using the D3-preferring, agonist radioligand, (11)CPHNO.

METHODS

Sixteen HH and sixteen CD individuals completed the Barratt Simplified Measure of Social Status (BSMSS) and underwent (11)CPHNO scanning to measure regional brain D2/3R binding potentials (BPND). Correlations between BPND and BSMSS scores were then assessed within each group.

RESULTS

Within HH and CD groups, inverse associations between BSMSS score and BPND were observed in the substantia nigra/ventral tegmental area (SN/VTA) and the ventral striatum, and for the CD group alone, the amygdala. After adjusting for body mass index and age, negative correlations remained significant in the SN/VTA for HH and in the amygdala for CD subjects.

CONCLUSION

These preliminary data utilizing a dopamine agonist tracer demonstrate, for the first time, an inverse association between social status and D2/3R availability in the D3R rich extrastriatal regions of HH and CD humans.

摘要

背景

先前在健康非人类灵长类动物和人类中的研究表明，社会地位与用拮抗剂放射性配体和正电子发射断层扫描（PET）成像的多巴胺2/3受体（D2/3R）可用性呈正相关。在非人类灵长类动物中的进一步研究表明，这种关系会因长期服用可卡因而受到破坏。这项探索性研究使用D3偏好性激动剂放射性配体[（11）C]（+）PHNO，研究了健康（HH）和可卡因依赖（CD）人类的社会地位与D2/3R可用性之间的关系。

方法

16名HH个体和16名CD个体完成了巴拉特社会地位简化测量（BSMSS），并接受了[（11）C]（+）PHNO扫描，以测量脑区D2/3R结合电位（BPND）。然后在每组中评估BPND与BSMSS评分之间的相关性。

结果

在HH组和CD组中，在黑质/腹侧被盖区（SN/VTA）和腹侧纹状体观察到BSMSS评分与BPND之间呈负相关，仅对于CD组，在杏仁核中也呈负相关。在调整体重指数和年龄后，HH组在SN/VTA以及CD组在杏仁核中的负相关仍然显著。

结论

这些使用多巴胺激动剂示踪剂的初步数据首次证明，在HH和CD人类富含D3R的纹状体区域外，社会地位与D2/3R可用性之间存在负相关。