de Laat Bart, Hoye Jocelyn, Stanley Gelsina, Hespeler Michelle, Ligi Jennifer, Mohan Varsha, Wooten Dustin W, Zhang Xiaomeng, Nguyen Thanh D, Key Jose, Colonna Giulia, Huang Yiyun, Nabulsi Nabeel, Patel Amar, Matuskey David, Morris Evan D, Tinaz Sule
Department of Radiology and Biomedical Imaging, Yale University, New Haven, CT, USA.
Department of Psychiatry, Yale University, New Haven, CT, USA.
NPJ Parkinsons Dis. 2024 Feb 9;10(1):34. doi: 10.1038/s41531-024-00641-1.
Parkinson's disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression of PD. We evaluated the dopaminergic system of patients with mild and early PD before and after a six-month program of intense exercise. Using F-FE-PE2I PET imaging, we measured dopamine transporter (DAT) availability in the striatum and substantia nigra. Using NM-MRI, we evaluated the neuromelanin content in the substantia nigra. Exercise reversed the expected decrease in DAT availability into a significant increase in both the substantia nigra and putamen. Exercise also reversed the expected decrease in neuromelanin concentration in the substantia nigra into a significant increase. These findings suggest improved functionality in the remaining dopaminergic neurons after exercise. Further research is needed to validate our findings and to pinpoint the source of any true neuromodulatory and neuroprotective effects of exercise in PD in large clinical trials.
帕金森病（PD）的特征是多巴胺能神经元进行性丧失。据报道，运动可减缓PD的临床进展。我们评估了轻度早期PD患者在进行为期六个月的高强度运动计划前后的多巴胺能系统。使用F-FE-PE2I PET成像，我们测量了纹状体和黑质中多巴胺转运体（DAT）的可用性。使用NM-MRI，我们评估了黑质中的神经黑色素含量。运动使黑质和壳核中DAT可用性预期的降低转变为显著增加。运动还使黑质中神经黑色素浓度预期的降低转变为显著增加。这些发现表明运动后剩余多巴胺能神经元的功能得到改善。需要进一步的研究来验证我们的发现，并在大型临床试验中确定运动对PD真正的神经调节和神经保护作用的来源。
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