Mouri Abdelkader, Diat Olivier, El Ghzaoui Abdeslam, Ly Isabelle, Dorandeu Christophe, Maurel Jean Claude, Devoisselle Jean-Marie, Legrand Philippe
Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France; Medesis Pharma, S.A, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
Institut de chimie séparative de Marcoule, ICSM UMR 5257 (CEA/CNRS/UM2/ENSCM), 30206 Bagnols sur Cèze, France.
J Colloid Interface Sci. 2015 Nov 1;457:152-61. doi: 10.1016/j.jcis.2015.06.010. Epub 2015 Jun 17.
The phase behavior of the four-components Peceol®/lecithin/ethanol/water system has been studied in a part of the phase diagram poor in water and varying the lecithin/Peceol® ratio. Using several complementary techniques such as Karl Fischer titration, rheology, polarized microscopy and SAXS measurements several nanostructures of the complex systems were identified. W/O microemulsion (L2) as well as an inverted hexagonal (H2) liquid-crystal phase were studied. The analysis of the different phase transitions allows us to understand the effect of lecithin on the water solubilization efficiency of this clear gel and to show its pharmaceutical interest among lecithin organogels.
在水含量较低且卵磷脂/聚乙二醇脂肪酸酯比例可变的相图部分，对四组分聚乙二醇脂肪酸酯/卵磷脂/乙醇/水体系的相行为进行了研究。使用卡尔费休滴定法、流变学、偏光显微镜和小角X射线散射测量等多种互补技术，确定了复合体系的几种纳米结构。研究了油包水微乳液（L2）以及反相六角（H2）液晶相。对不同相变的分析使我们能够了解卵磷脂对这种透明凝胶的水增溶效率的影响，并表明其在卵磷脂有机凝胶中的药学价值。
