Institut Charles Gerhardt Montpellier, UMR 5253 CNRS-ENSCM-UM2-UM1, Equipe MACS, 8 rue de l'Ecole Normale, 34296 Montpellier, France; Medesis Pharma, Avenue du Golf, L'Orée des Mas, Les Cyprès, 34670 Baillargues, France.
Institut de Chimie Séparative de Marcoule, ICSM UMR 5257 (CEA/CNRS/UM2/ENSCM), 30206 Bagnols sur Cèze, France.
J Colloid Interface Sci. 2014 Feb 15;416:139-46. doi: 10.1016/j.jcis.2013.10.058. Epub 2013 Nov 8.
The phase diagram of the four component system Peceol®/lecithin/ethanol/water was studied at 25°C and at a fixed fraction of ethanol. It shows an isotropic W/O microemulsion phase, biphasic liquid system and Liquid crystalline phases. The stabilizing effect of lecithin with the fluidifying effect of ethanol on the microemulsion based on long chain glycerides provides an effective combination to solubilize a large amount of water. Some structural transitions in the phase diagram were investigated as a function of water content using conductivity, rheology, Karl Fisher titration, optical microscopy and SAXS measurements. The results show no change in the microstructure of the isotropic liquid upon phase separation in the liquid biphasic area. However, in the water rich region, migration of ethanol to the external aqueous phase at the expense of the saturated microemulsion promotes the formation of liquid crystalline phases. As a function of water content, the structural change to the liquid crystalline phases follows: isotropic phase L2 → Inverted hexagonal phase H2 → Inverted hexagonal H2/lamellar Lα phases.
在 25°C 下，研究了四组分体系 Peceol®/卵磷脂/乙醇/水的相图，并固定了乙醇的分数。它显示各向同性的 W/O 微乳液相、双液相系统和液晶相。卵磷脂的稳定作用和乙醇的流态化作用对基于长链甘油酯的微乳液提供了有效组合，以溶解大量的水。使用电导率、流变学、卡尔费休滴定、光学显微镜和 SAXS 测量，研究了相图中一些结构转变作为含水量的函数。结果表明，在双液相区发生相分离时，各向同性液体的微观结构没有变化。然而，在富水区，乙醇向外部水相迁移，牺牲了饱和微乳液，促进了液晶相的形成。随着含水量的变化，液晶相的结构变化如下：各向同性相 L2→反相六角相 H2→反相六角 H2/层状 Lα 相。
