Ding Y, Rao S-X, Zhu T, Chen C-Z, Li R-C, Zeng M-S
Department of Radiology, Zhongshan Hospital of Fudan University, No. 180, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Department of Radiology, Zhongshan Hospital of Fudan University, No. 180, Fenglin Road, Xuhui District, Shanghai, 200032, China.
Clin Radiol. 2015 Oct;70(10):1096-103. doi: 10.1016/j.crad.2015.04.014. Epub 2015 Jul 9.
To evaluate the utility of T1 mapping on gadoxetic acid-enhanced magnetic resonance imaging (MRI) and diffusion-weighted imaging (DWI) for staging liver fibrosis.
This retrospective study was approved by the institutional review board and included 145 patients (mean age: 54 years old; 115 men and 30 women). Necro-inflammatory activity grade (G) and liver fibrosis stage (S) were histopathologically determined. T1 relaxation time and apparent diffusion coefficient (ADC) of the liver were measured and the reduction rate of the T1 relaxation time (Δ%) was calculated. T1 relaxation time measurements were compared with ADC values according to S/G scores.
Unenhanced hepatobiliary phase (HBP) and Δ% of T1 relaxation times showed significant correlations with S/G scores (rho: 0.28, 0.51, -0.35 for the S score, 0.26, 0.39, -0.26 for the G score, respectively, p<0.05). ADC values showed significant correlation with the S score (rho: -0.17, p = 0.04) and did not correlate significantly with the G score (rho: -0.07, p = 0.39). The areas under receiver operator characteristics (AUC) curve of unenhanced HBP, Δ% T1 relaxation time, and the ADC value were 0.68, 0.82, 0.71, 0.61 for the identification of S ≥ 3, and 0.63, 0.68, 0.62, 0.52 for the identification of G ≥ 3, respectively. The HBP T1 relaxation time was better than that of ADC for identification of S ≥ 3 (p = 0.0005) and G ≥ 3 (p = 0.014).
The HBP T1 relaxation time measurement on gadoxetic acid-enhanced MRI images might be a potential biomarker in the staging of hepatic fibrosis, and was more accurate than the ADC measurement.
评估钆塞酸增强磁共振成像（MRI）和扩散加权成像（DWI）中的T1 mapping对肝纤维化分期的应用价值。
本回顾性研究经机构审查委员会批准，纳入145例患者（平均年龄：54岁；男性115例，女性30例）。通过组织病理学确定坏死性炎症活动度分级（G）和肝纤维化分期（S）。测量肝脏的T1弛豫时间和表观扩散系数（ADC），并计算T1弛豫时间的降低率（Δ%）。根据S/G评分比较T1弛豫时间测量值与ADC值。
未增强的肝胆期（HBP）和T1弛豫时间的Δ%与S/G评分均呈显著相关性（S评分的rho值分别为0.28、0.51、-0.35，G评分的rho值分别为0.26、0.39、-0.26，p<0.05）。ADC值与S评分呈显著相关性（rho：-0.17，p = 0.04），与G评分无显著相关性（rho：-0.07，p = 0.39）。未增强HBP、Δ% T1弛豫时间和ADC值在识别S≥3时的受试者操作特征（AUC）曲线下面积分别为0.68、0.82、0.71、0.61，在识别G≥3时分别为0.63、0.68、0.62、0.52。在识别S≥3（p = 0.0005）和G≥3（p = 0.014）时，HBP的T1弛豫时间比ADC更具优势。
钆塞酸增强MRI图像上的HBP T1弛豫时间测量可能是肝纤维化分期的潜在生物标志物，且比ADC测量更准确。
Zotero 插件