Department of Medical Imaging, Zhuhai People's Hospital, Zhuhai Hospital Affiliated With Jinan University, Zhuhai, 519000, Guangdong, People's Republic of China.
Department of Radiology, Affiliated Matern and Child Care Hospital of Nantong University, Nantong, 226000, Jiangsu, People's Republic of China.
Radiol Med. 2021 Sep;126(9):1149-1158. doi: 10.1007/s11547-021-01382-4. Epub 2021 Jun 8.
This study aimed to explore the impact of different acquisition times on the evaluation of liver function levels in chronic hepatitis B using Gd-EOB-DTPA-enhanced T1 positioning technology under 3.0 Tesla magnetic resonance imaging (MRI).
A total of 146 patients with chronic hepatitis B (CHB) were classified into four groups as follows: chronic hepatitis B without liver cirrhosis (CH, 22 cases), liver cirrhosis with Child-Pugh classification A (LCA 63 cases), Child-Pugh B (LCB 47 cases) and Child-Pugh C (LCC 14 cases). Normal liver function (NLF) group was composed of 23 persons who had healthy liver and no medical histories of hepatitis. T1 mapping images were performed before and after administration of Gd-EOB-DPTA using Look-Locker sequence. Changes in T1 relaxation time (T1rt), the reduction rate of T1 relaxation time (ΔT1) and the increase in T1 relaxation rate (ΔR1) of liver over time (at 5, 10, 15 and 20 min) were investigated and compared among all five groups using a one-way analysis of variance (ANOVA). The Spearman's rank correlation coefficient (r) was used to show the correlations of these parameters in different liver function groups.
In the NLF, CH, LCA and LCB groups, postT1 gradually decreased, while the ΔT1 and ΔR1 gradually increased with time. The parameters were compared between different liver function levels at the same time point, and the differences were statistically significant except for NLF-CH, NLF-LCA and CH-LCA. There was no significant difference in the area under the ROC curve of other parameters at 10, 15 and 20 min. At each time point, no correlation was found between preT1rt and the degrees of liver function. PostT1rt was positively correlated with liver function classification, while ΔT1 and ΔR1 were negatively correlated with liver function classification.
Gd-EOB-DTPA-enhanced T1 mapping magnetic resonance imaging is beneficial to assess liver function. Using the Gd-EOB-DTPA to enhance T1 mapping imaging to assess liver function can shorten the observation time of the hepatobiliary period and 10 min after enhancement may be the best time point.
本研究旨在探讨在 3.0 特斯拉磁共振成像（MRI）下使用 Gd-EOB-DTPA 增强 T1 定位技术时，不同采集时间对慢性乙型肝炎肝功能水平评估的影响。
将 146 例慢性乙型肝炎（CHB）患者分为以下四组：无肝硬化的慢性乙型肝炎（CH，22 例）、Child-Pugh 分级 A 的肝硬化（LCA，63 例）、Child-Pugh B 的肝硬化（LCB，47 例）和 Child-Pugh C 的肝硬化（LCC，14 例）。正常肝功能（NLF）组由 23 名健康肝脏且无肝炎病史的人员组成。使用 Look-Locker 序列在 Gd-EOB-DPTA 给药前后进行 T1 映射成像。使用单因素方差分析（ANOVA）比较所有五组之间随时间变化的 T1 弛豫时间（T1rt）、T1 弛豫时间降低率（ΔT1）和 T1 弛豫率增加率（ΔR1）的变化。采用 Spearman 秩相关系数（r）表示不同肝功能组之间这些参数的相关性。
在 NLF、CH、LCA 和 LCB 组中，随着时间的推移，postT1 逐渐降低，而ΔT1 和ΔR1 逐渐增加。在同一时间点比较不同肝功能水平的参数，除了 NLF-CH、NLF-LCA 和 CH-LCA 外，差异均有统计学意义。在 10、15 和 20 min 时，其他参数的 ROC 曲线下面积没有差异。在每个时间点，preT1rt 与肝功能分级之间均无相关性。postT1rt 与肝功能分级呈正相关，而ΔT1 和ΔR1 与肝功能分级呈负相关。
Gd-EOB-DTPA 增强 T1 映射磁共振成像有助于评估肝功能。使用 Gd-EOB-DTPA 增强 T1 映射成像评估肝功能可以缩短肝胆期的观察时间，增强后 10 min 可能是最佳时间点。
