催化剂控制的尿素键联烯烃的氨-与氧-乙酰氧基化反应：环状脲和异脲的高效合成。
Catalyst-Controlled Amino- versus Oxy-Acetoxylation of Urea-Tethered Alkenes: Efficient Synthesis of Cyclic Ureas and Isoureas.
机构信息
Department of Chemistry, Zhejiang University, Hangzhou 310027, China.
出版信息
Org Lett. 2015 Aug 7;17(15):3758-61. doi: 10.1021/acs.orglett.5b01741. Epub 2015 Jul 13.
PMID:26166021
Abstract
A catalyst-controlled vicinal amino- versus oxy-acetoxylation of alkenes with PhI(OAc)2 as the oxidant is described. The divergent synthesis of cyclic ureas and isoureas was achieved in good yields under mild conditions employing ambident urea nucleophiles. Both terminal and internal alkenes are compatible with this reaction protocol.
摘要
描述了一种由 PhI(OAc)2 作为氧化剂，通过催化剂控制的烯键邻位氨基-与氧-乙酰氧基化反应。在温和条件下，使用双功能脲亲核试剂，以良好的收率实现了环状脲和异脲的发散合成。该反应方案适用于末端烯烃和内部烯烃。
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