PS-BEMP作为用于向贫电子烯烃进行磷迈克尔加成反应的碱性催化剂。

PS-BEMP as a basic catalyst for the phospha-Michael addition to electron-poor alkenes.

作者信息

Strappaveccia Giacomo, Bianchi Luca, Ziarelli Simone, Santoro Stefano, Lanari Daniela, Pizzo Ferdinando, Vaccaro Luigi

机构信息

Laboratory of Green Synthetic Organic Chemistry, CEMIN - Dipartimento di Chimica, Università di Perugia, Via Elce di Sotto 8, Perugia, Italy.

出版信息

Org Biomol Chem. 2016 Apr 14;14(14):3521-5. doi: 10.1039/c6ob00242k. Epub 2016 Mar 14.

DOI:10.1039/c6ob00242k

PMID:26974873

Abstract

PS-BEMP was used as a heterogeneous catalyst for the phospha-Michael addition of phosphorus nucleophiles to a variety of electron-poor alkenes. The addition reactions were generally performed with equimolar amounts of reagents under solvent free conditions. The protocol proved to be very efficient for the addition to aromatic, non-aromatic and cyclic ketones, giving good yields (78-85%) in all cases. The protocol was also extended with good results to α,β-unsaturated esters and nitriles. This demonstrates that PS-BEMP is a good catalyst for the phospha-Michael addition to electron-poor alkenes.

摘要

聚苯乙烯负载的BEMP（PS-BEMP）被用作多相催化剂，用于磷亲核试剂对各种缺电子烯烃的磷迈克尔加成反应。加成反应通常在无溶剂条件下使用等摩尔量的试剂进行。该方法被证明对于加成到芳香族、非芳香族和环状酮非常有效，在所有情况下都能得到良好的产率（78-85%）。该方法也成功扩展到α,β-不饱和酯和腈，结果良好。这表明PS-BEMP是用于缺电子烯烃磷迈克尔加成反应的良好催化剂。