Lindner Henry, Carreira Erick M
Laboratory of Organic Chemistry, Department of Chemistry and Applied Biosciences, ETH Zürich, 8093 Zurich, Switzerland.
Org Lett. 2025 Jan 17;27(2):704-708. doi: 10.1021/acs.orglett.4c04695. Epub 2025 Jan 8.
We report intramolecular photocatalyzed cycloisomerization of unactivated olefins with pendant nucleophiles. The reaction proceeds under mild conditions and utilizes guanidines, ureas, isoureas, isothioureas, and carbonates to yield several different five-, six-, and seven-membered heterocycles. Use of benzothiazinoquinoxaline as an organophotocatalyst and cobalt-salen catalyst obviates the need for a stoichiometric oxidant or reductant.
我们报道了未活化烯烃与侧链亲核试剂的分子内光催化环异构化反应。该反应在温和条件下进行，利用胍、脲、异脲、异硫脲和碳酸盐生成几种不同的五元、六元和七元杂环。使用苯并噻嗪并喹喔啉作为有机光催化剂和钴-萨伦催化剂避免了对化学计量的氧化剂或还原剂的需求。
