参松养心胶囊中的螺环生物碱

Spiroalkaloids from Shensong Yangxin capsule.

作者信息

Ding Bo, Dai Yi, Hou Yun-Long, Yao Xin-Sheng

机构信息

a Guangdong Institute for Food and Drug Control , Guangzhou 510180 , China.

出版信息

J Asian Nat Prod Res. 2015 May;17(5):559-66. doi: 10.1080/10286020.2015.1047354.

DOI:10.1080/10286020.2015.1047354

PMID:26166310

Abstract

Four spiroalkaloids, including a new compound shensongine A (1), were isolated from the anti-arrhythmic TCM formula Shensong Yangxin capsule. Their structures were determined on the basis of spectroscopic analysis. Compounds 1 and 3 displayed cardiovascular activities by shortened APD in rat myocardial cells. These compounds were possibly generated from precursors in different composed herbal medicines during the processing of the TCM formula.

摘要

从抗心律失常中药复方参松养心胶囊中分离得到4种螺环生物碱，包括一个新化合物参松碱A（1）。通过光谱分析确定了它们的结构。化合物1和3通过缩短大鼠心肌细胞的动作电位时程显示出心血管活性。这些化合物可能是在中药复方炮制过程中由不同组成草药中的前体产生的。