从凹叶黄皮茎中提取的抗炎酰胺生物碱。

Anti-inflammatory amide alkaloids from the stems of Clausena emarginata.

作者信息

Xia Hong-Min, Li Chuang-Jun, Yang Jing-Zhi, Ma Jie, Li Li, Zhang Dan, Bao Xiu-Qi, Zhang Dong-Ming

机构信息

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College , Beijing 100050 , China.

出版信息

J Asian Nat Prod Res. 2014 Oct;16(10):971-5. doi: 10.1080/10286020.2014.943750. Epub 2014 Sep 24.

DOI:10.1080/10286020.2014.943750

PMID:25248461

Abstract

Two new amide alkaloids, clauemaramide A (1) and clauemaramide B (2), and three known analogs were isolated from the stems of Clausena emarginata. Their structures were determined on the basis of spectroscopic analyses. The absolute configurations of 1 and 2 were confirmed by CD spectroscopy. Compound 3 showed moderate inhibitory effects on LPS-induced NO production (IC₅₉ value = 4.9 μM).

摘要

从凹叶黄皮的茎中分离出两种新的酰胺生物碱，即凹叶黄皮酰胺A（1）和凹叶黄皮酰胺B（2），以及三种已知的类似物。它们的结构通过光谱分析确定。通过圆二色光谱（CD光谱）确定了1和2的绝对构型。化合物3对脂多糖（LPS）诱导的一氧化氮（NO）生成表现出中等程度的抑制作用（IC₅₀值 = 4.9 μM）。