Donaldson Abigail A, Gordon Catherine M
Hasbro Children's Hospital and Alpert Medical School of Brown University, Providence, RI.
Metabolism. 2015 Sep;64(9):943-51. doi: 10.1016/j.metabol.2015.06.007. Epub 2015 Jun 14.
Anorexia nervosa (AN) is a psychiatric illness with profound medical consequences. Among the many adverse physical sequelae of AN, bone health is impacted by starvation and can be permanently impaired over the course of the illness. In this review of skeletal complications associated with eating disorders, we discuss the epidemiology, neuroendocrine changes, adolescent vs. adult skeletal considerations, orthopedic concerns, assessment of bone health, and treatment options for individuals with AN. The focus of the review is the skeletal sequelae associated with anorexia nervosa, but we also briefly consider other eating disorders that may afflict adolescents and young adults. The review presents updates to the field of bone health in AN, and also suggests knowledge gaps and areas for future investigation.
神经性厌食症（AN）是一种具有严重医学后果的精神疾病。在AN众多不良的身体后遗症中，骨骼健康会受到饥饿的影响，并且在疾病过程中可能会受到永久性损害。在这篇关于饮食失调相关骨骼并发症的综述中，我们讨论了流行病学、神经内分泌变化、青少年与成人骨骼方面的考量、骨科问题、骨骼健康评估以及AN患者的治疗选择。综述的重点是与神经性厌食症相关的骨骼后遗症，但我们也简要考虑了可能困扰青少年和年轻人的其他饮食失调症。这篇综述介绍了AN领域骨骼健康方面的最新进展，还指出了知识空白和未来研究的方向。
