transgender 女孩青春期阻断前的骨密度和骨髓成分：病例系列研究。
Bone density and bone marrow composition in transgender girls prior to pubertal blockade: A case series.
机构信息
Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, United States of America; Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, United States of America.
Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, 300 Longwood Ave, Boston, MA 02115, United States of America.
出版信息
Bone. 2022 Sep;162:116454. doi: 10.1016/j.bone.2022.116454. Epub 2022 Jun 3.
PURPOSE
To determine bone mineral density (BMD) of transgender girls before pubertal blockade, and correlate with lifestyle and clinical variables.
METHODS
Six transfemale peri-pubertal girls had knee magnetic resonance imaging (MRI) with T1-weighted images and single-voxel proton magnetic resonance spectroscopy (MRS). BMD measurements were obtained via dual-energy X-ray absorptiometry. Questionnaires about physical activity, diet, and the Eating Attitudes Test (EAT-26) were completed. The T2 relaxation rate of water (R2 = 1/T2 in s -1) was correlated with scores on surveys.
RESULTS
Three participants (50 %) had a low bone mineral density for age based on total body less head Z-score less than -2; two participants (33 %) had a low BMD for age at lumbar spine. All had EAT-26 scores below threshold for clinical concern. All participants self-reported regular exercise. Bone marrow MR variables (T1, fat fraction, unsaturation index and R2 of water) were not correlated with DXA measures.
CONCLUSIONS
Participants had low BMD on beginning pubertal blockade. Clinicians should consider monitoring BMD among youth AMAB, a group at potential risk for poor bone health.
目的
在青春期阻滞剂治疗前，测定跨性别女孩的骨矿物质密度（BMD），并与生活方式和临床变量相关联。
方法
对 6 名青春期前的跨性别女性进行膝关节磁共振成像（MRI）检查，包括 T1 加权图像和单体质子磁共振波谱（MRS）。采用双能 X 射线吸收法进行 BMD 测量。完成了关于身体活动、饮食和饮食态度测试（EAT-26）的问卷。水的 T2 弛豫率（R2=1/T2，单位为 s-1）与调查评分相关。
结果
3 名参与者（50%）的全身（不包括头部）Z 分数低于-2，总骨密度低于年龄；2 名参与者（33%）的腰椎骨密度低于年龄。所有参与者的 EAT-26 评分均低于临床关注的阈值。所有参与者均报告有规律的运动。骨髓 MRI 变量（T1、脂肪分数、不饱和指数和水的 R2）与 DXA 测量值无关。
结论
在开始青春期阻滞剂治疗时，参与者的 BMD 较低。临床医生应考虑对 AMAB 青少年的 BMD 进行监测，这是一组存在潜在骨骼健康不良风险的人群。
Zotero 插件