透明质酸膀胱内治疗对膀胱疼痛综合征的疗效：中国初步经验及系统评价
The effects of intravesical therapy with hyaluronic acid for painful bladder syndrome: Preliminary Chinese experience and systematic review.
作者信息
Han Xiao-Min, Wu Xin-Hua, Li Bing, Pan Feng, Li Wen-Cheng, Liu Shu-Lan, Zeng Fu-Qing, Chen Min
机构信息
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
出版信息
Taiwan J Obstet Gynecol. 2015 Jun;54(3):240-7. doi: 10.1016/j.tjog.2014.09.007.
OBJECTIVE
To present the preliminary results of treating a series of Chinese patients with painful bladder syndrome/interstitial cystitis (PBS/IC) using intravesical hyaluronic acid (HA).
MATERIALS AND METHODS
A series of 13 patients with PBS/IC received first-line therapy followed by HA once-a-week for 4 weeks and then once monthly for 4 months. Outcomes measured included O'Leary-Sant Interstitial Cystitis Symptom Index (ICSI) and Interstitial Cystitis Problem Index (ISPI) scores, voiding frequency, and bladder capacity.
RESULTS
ISPI and ICSI scores were significantly (p < 0.001) decreased after treatment [median change (interquartile range): ISPI = 2 (2-3); ICSI = 3 (2-3)]. Voiding frequency and functional bladder capacity were significantly (p < 0.001) decreased [median change: 7 (6-8) times/d] and increased [median change: 190 (116-233) mL], respectively after treatment.
CONCLUSION
Our case series supports the efficacy of intravesical HA in the treatment of PBS/IC.
目的
介绍使用膀胱内透明质酸（HA）治疗一系列中国疼痛性膀胱综合征/间质性膀胱炎（PBS/IC）患者的初步结果。
材料与方法
13例PBS/IC患者接受一线治疗，随后每周一次HA治疗，共4周，然后每月一次，共4个月。测量的结果包括奥利里-桑特间质性膀胱炎症状指数（ICSI）和间质性膀胱炎问题指数（ISPI）评分、排尿频率和膀胱容量。
结果
治疗后ISPI和ICSI评分显著降低（p < 0.001）[中位数变化（四分位间距）：ISPI = 2（2 - 3）；ICSI = 3（2 - 3）]。治疗后排尿频率显著降低（p < 0.001）[中位数变化：7（6 - 8）次/天]，功能性膀胱容量显著增加（p < 0.001）[中位数变化：190（116 - 233）mL]。
结论
我们的病例系列支持膀胱内HA治疗PBS/IC的疗效。
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