杂环苯基磺酰基和4-氨基苯基磺酰基甲脒的合成、结构及抗菌活性
Synthesis, structure, and antimicrobial activity of heterocyclic phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides.
作者信息
Gobis Katarzyna, Foks Henryk, Wiśniewska Katarzyna, Dąbrowska-Szponar Maria, Augustynowicz-Kopeć Ewa, Napiórkowska Agnieszka, Sikorski Artur
机构信息
Department of Organic Chemistry, Medical University of Gdańsk, Gdańsk, Poland.
Department of Medicinal Microbiology, Chair of Microbiology, Medical University of Gdańsk, Gdańsk, Poland.
出版信息
Monatsh Chem. 2012;143(8):1161-1169. doi: 10.1007/s00706-012-0769-6. Epub 2012 May 15.
Abstract
ABSTRACT
A series of novel phenylsulfonyl- and 4-aminophenylsulfonyl-carboximidamides were synthesized by condensation of sulfonamides with heterocyclic methyl carbimidates obtained from heterocyclic carbonitriles and used 'at its inception.' The molecular structure of the obtained compounds is discussed. Compounds possessing heterocyclic systems with a nitrogen atom in the α position to the functional group showed a different single-crystal structure than expected. The synthesized derivatives were evaluated for antimicrobial activities: tuberculostatic, antibacterial, and antifungal.
摘要
摘要
通过磺酰胺与由杂环腈获得的杂环甲基氨基甲酰亚胺缩合，合成了一系列新型苯基磺酰基和4-氨基苯基磺酰基-羧基亚胺酰胺，并在其初始阶段使用。讨论了所得化合物的分子结构。在官能团α位具有含氮原子杂环体系的化合物显示出与预期不同的单晶结构。对合成的衍生物进行了抗菌活性评估：抗结核、抗菌和抗真菌活性。
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