无溶剂条件下超声介导合成α,α'-双（苯甲酰甲基）苯胺
Ultrasound-mediated synthesis of ,-bis(phenacyl)aniline under solvent-free conditions.
作者信息
He Jingyu, Shi Lanxiang, Liu Sijie, Jia Peng, Wang Juan, Hu Ruisheng
机构信息
College of Chemical Engineering, Shijiazhuang University, Shijiazhuang, 050035 People's Republic of China.
出版信息
Monatsh Chem. 2014;145(1):213-216. doi: 10.1007/s00706-013-0978-7. Epub 2013 Apr 26.
Abstract
ABSTRACT
An efficient method for the synthesis of ,-bis(phenacyl)anilines was developed via smooth condensation of anilines with α-bromoacetophenones in the presence of sodium carbonate as acid acceptor and polyethylene glycol 400 (PEG 400) as catalyst at room temperature under solvent-free conditions by using 350 W ultrasound irradiation. In addition to experimental simplicity, the main advantages of the procedure are mild conditions, short reaction times (30-45 min), and high yields (73-83 %).
摘要
摘要
开发了一种高效合成α,α'-双（苯甲酰甲基）苯胺的方法，该方法是在无溶剂条件下，以碳酸钠作为酸接受体、聚乙二醇400（PEG 400）作为催化剂，通过苯胺与α-溴苯乙酮在室温下进行顺利缩合反应，并使用350W超声辐射实现的。除了实验操作简单外，该方法的主要优点是条件温和、反应时间短（30 - 45分钟）且产率高（73 - 83%）。
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