Ghomi Javad Safaei, Akbarzadeh Zeinab
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, IR, Iran.
Department of Organic Chemistry, Faculty of Chemistry, University of Kashan, Kashan 51167, IR, Iran.
Ultrason Sonochem. 2018 Jan;40(Pt A):78-83. doi: 10.1016/j.ultsonch.2017.06.022. Epub 2017 Jun 27.
The novel and green procedure to synthesis of 3-substituted coumarins was performed through the Knoevenagel condensation between various salicylaldehydes and 1,3-dicarbonyl compounds by MgFeO nanoparticles as an efficient catalyst under solvent-free condition using ultrasound irradiation. The nano catalyst was easily recovered by an external magnet and reused for several times without significant loss of its catalytic performance. Compare to the previous works, this progressive protocol have advantages such as simple workup, high yields of coumarins, solvent free condition, environmentally benign and short reaction times.
通过MgFeO纳米颗粒作为高效催化剂，在无溶剂条件下利用超声辐射，使各种水杨醛与1,3 - 二羰基化合物之间发生Knoevenagel缩合反应，实现了一种新颖的绿色合成3 - 取代香豆素的方法。该纳米催化剂可通过外部磁铁轻松回收，并能重复使用多次，其催化性能无明显损失。与先前的工作相比，这一先进的方法具有后处理简单、香豆素产率高、无溶剂条件、环境友好以及反应时间短等优点。
