Lin Jiajin, Jiang Fuguang, Wen Jianchuan, Lv Wei, Porteous Nuala, Deng Ying, Sun Yuyu
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854.
Biomedical Engineering Program, University of South Dakota, Sioux Falls, SD 57107.
Polymer (Guildf). 2015 Jun 26;68:92-100. doi: 10.1016/j.polymer.2015.05.014.
The objective of this study was to evaluate the effects of fluorination on the antimicrobial and biofilm-controlling activities of N-halamine-based additives for polymers. A fluorinated N-halamine, 1-chloro-3-1H,1H,2H,2H-perflurooctyl-5,5-dimetylhydantoin (Cl-FODMH), and its un-fluorinated counterpart, 1-chloro-3-octyl-5,5-dimethylhydantoin (Cl-ODMH), were synthesized and characterized with FT-IR, H-NMR, and DSC studies. Polyurethane (PU) films containing Cl-ODMH and Cl-FODMH as antimicrobial additives were fabricated through solvent casting. With the same additive contents (1wt%-5 wt%), PU films with Cl-FODMH showed higher contact angle values. AFM, SEM and DSC results revealed that while Cl-ODMH distributed evenly within PU, Cl-FODMH aggregated and formed macro-domains in PU. Antimicrobial studies showed that PU films with Cl-ODMH had higher antimicrobial and biofilm-controlling potency against Gram-positive and Gram-negative bacteria than PU samples with Cl-FODMH. These results demonstrated the importance of distribution of additives in polymers on antimicrobial performances, shedding lights on future antimicrobial material design strategies.
本研究的目的是评估氟化对聚合物用基于N-卤胺的添加剂的抗菌和生物膜控制活性的影响。合成了一种氟化N-卤胺,1-氯-3-(1H,1H,2H,2H-全氟辛基)-5,5-二甲基乙内酰脲(Cl-FODMH)及其未氟化的对应物1-氯-3-辛基-5,5-二甲基乙内酰脲(Cl-ODMH),并通过傅里叶变换红外光谱(FT-IR)、氢核磁共振(H-NMR)和差示扫描量热法(DSC)研究对其进行了表征。通过溶液浇铸制备了含有Cl-ODMH和Cl-FODMH作为抗菌添加剂的聚氨酯(PU)薄膜。在相同的添加剂含量(1wt%-5 wt%)下,含Cl-FODMH的PU薄膜显示出更高的接触角值。原子力显微镜(AFM)、扫描电子显微镜(SEM)和DSC结果表明,虽然Cl-ODMH在PU中均匀分布,但Cl-FODMH在PU中聚集并形成宏观区域。抗菌研究表明,含Cl-ODMH的PU薄膜对革兰氏阳性菌和革兰氏阴性菌的抗菌和生物膜控制能力高于含Cl-FODMH的PU样品。这些结果证明了添加剂在聚合物中的分布对抗菌性能的重要性,为未来抗菌材料的设计策略提供了思路。