Luo Jie, Porteous Nuala, Lin Jiajin, Sun Yuyu
Department of Chemistry, University of Massachusetts Lowell, Lowell, MA, USA.
Department of Comprehensive Dentistry, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
J Bioact Compat Polym. 2015 Mar;30(2):157-166. doi: 10.1177/0883911515569007.
Hydroxyl groups were introduced onto polyurethane surfaces through 1,6-hexamethylene diisocyanate activation, followed by diethanolamine hydroxylation. Polymethacrylamide was covalently attached to the hydroxylated polyurethane through surface grafting polymerization of methacrylamide using cerium (IV) ammonium nitrate as an initiator. After bleach treatment, the amide groups of the covalently bound polymethacrylamide chains were transformed into N-halamines. The new N-halamine-immobilized polyurethane provided a total sacrifice of 10-10 colony forming units per milliliter of (Gram-positive bacteria), (Gram-negative bacteria), and (fungi) within 10 min and successfully prevented bacterial and fungal biofilm formation. The antimicrobial and biofilm-controlling effects were both durable and rechargeable, pointing to great potentials of the new acyclic N-halamine-immobilized polyurethane for a broad range of related applications.
通过1,6-己二异氰酸酯活化将羟基引入聚氨酯表面，随后进行二乙醇胺羟基化。使用硝酸铈（IV）铵作为引发剂，通过甲基丙烯酰胺的表面接枝聚合将聚甲基丙烯酰胺共价连接到羟基化的聚氨酯上。经过漂白处理后，共价结合的聚甲基丙烯酰胺链的酰胺基团转化为N-卤胺。新的固定有N-卤胺的聚氨酯在10分钟内每毫升可完全杀灭10⁻¹⁰个菌落形成单位的金黄色葡萄球菌（革兰氏阳性菌）、大肠杆菌（革兰氏阴性菌）和白色念珠菌（真菌），并成功防止细菌和真菌生物膜的形成。抗菌和生物膜控制效果既持久又可再充电，表明新型无环固定有N-卤胺的聚氨酯在广泛的相关应用中具有巨大潜力。
