疟原虫质体 HSP70s 是功能适应疟原虫生活周期的。
Plasmodial HSP70s are functionally adapted to the malaria parasite life cycle.
机构信息
Parasitology, Philipps University Marburg Marburg, Germany.
Centre for Chronic Disease Prevention and Management, College of Health and Biomedicine, Victoria University Melbourne, VIC, Australia ; Biomedical Biotechnology Research Unit, Department of Biochemistry and Microbiology, Rhodes University Grahamstown, South Africa.
出版信息
Front Mol Biosci. 2015 Jun 26;2:34. doi: 10.3389/fmolb.2015.00034. eCollection 2015.
Abstract
The human malaria parasite, Plasmodium falciparum, encodes a minimal complement of six heat shock protein 70s (PfHSP70s), some of which are highly expressed and are thought to play an important role in the survival and pathology of the parasite. In addition to canonical features of molecular chaperones, these HSP70s possess properties that reflect functional adaptation to a parasitic life style, including resistance to thermal insult during fever periods and host-parasite interactions. The parasite even exports an HSP70 to the host cell where it is likely to be involved in host cell modification. This review focuses on the features of the PfHSP70s, particularly with respect to their adaptation to the malaria parasite life cycle.
摘要
人类疟疾寄生虫，恶性疟原虫，编码一个最小的六种热休克蛋白 70s（PfHSP70s）的成分，其中一些高度表达，被认为在寄生虫的生存和病理学中发挥重要作用。除了分子伴侣的典型特征外，这些 HSP70s 还具有反映对寄生生活方式的功能适应的特性，包括在发热期间对热损伤的抗性以及宿主-寄生虫相互作用。寄生虫甚至将 HSP70 输出到宿主细胞，在那里它可能参与宿主细胞的修饰。本综述重点介绍 PfHSP70s 的特征，特别是它们对疟原虫生命周期的适应。
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