Marvel Douglas, Gabrilovich Dmitry I
J Clin Invest. 2015 Sep;125(9):3356-64. doi: 10.1172/JCI80005. Epub 2015 Jul 13.
Our understanding of the role of myeloid-derived suppressor cells (MDSCs) in cancer is becoming increasingly complex. In addition to their eponymous role in suppressing immune responses, they directly support tumor growth, differentiation, and metastasis in a number of ways that are only now beginning to be appreciated. It is because of this increasingly complex role that these cells may become an important factor in the treatment of human cancer. In this Review, we discuss the most pertinent and controversial issues of MDSC biology and their role in promoting cancer progression and highlight how these cells may be used in the clinic, both as prognostic factors and as therapeutic targets.
我们对髓系来源的抑制性细胞(MDSCs)在癌症中作用的理解正变得越来越复杂。除了其在抑制免疫反应方面的固有作用外,它们还以多种方式直接支持肿瘤生长、分化和转移,而这些方式直到现在才开始被认识到。正是由于这些细胞的作用日益复杂,它们可能成为人类癌症治疗中的一个重要因素。在本综述中,我们讨论了MDSC生物学中最相关和最具争议的问题及其在促进癌症进展中的作用,并强调了这些细胞如何可在临床上用作预后因素和治疗靶点。