Laboratory of Cellular and Molecular Immunology, Vrije Universiteit Brussel, Brussels, Belgium; Laboratory of Myeloid Cell Immunology, VIB Center for Inflammation Research, Brussels, Belgium.
IDLab, Department of Information Technology, Ghent University - IMEC, Ghent, Belgium; Data Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.
Cell Immunol. 2018 Aug;330:188-201. doi: 10.1016/j.cellimm.2018.02.008. Epub 2018 Feb 14.
Tumors of various histological origins show abundant infiltration of myeloid cells from early stages of disease progression. These cells have a profound impact on antitumor immunity and influence fundamental processes that underlie malignancy, including neoangiogenesis, sustained cancer cell proliferation, metastasis and therapy resistance. For these reasons, development of therapeutic approaches to deplete or reprogram myeloid cells in cancer is an emerging field of interest. However, knowledge about the heterogeneity of myeloid cells in tumors and their variability between patients and disease stages is still limited. In this review, we summarize the most recent advances in our understanding about how the phenotype of tumor-associated macrophages, monocytes, neutrophils, myeloid-derived suppressor cells and dendritic cells is dictated by their ontogeny, activation status and localization. We also outline major open questions that will only be resolved by applying high-dimensional single-cell technologies and systems biology approaches in the analysis of the tumor microenvironment.
各种组织来源的肿瘤在疾病进展的早期就表现出大量髓系细胞浸润。这些细胞对肿瘤免疫有深远影响，并影响恶性肿瘤的基本过程，包括新生血管生成、持续的癌细胞增殖、转移和治疗耐药。出于这些原因，开发治疗方法以耗尽或重编程癌症中的髓系细胞是一个新兴的研究领域。然而，关于肿瘤中髓系细胞的异质性及其在患者和疾病阶段之间的可变性的知识仍然有限。在这篇综述中，我们总结了关于肿瘤相关巨噬细胞、单核细胞、中性粒细胞、髓系来源抑制细胞和树突状细胞的表型如何受到其个体发生、激活状态和定位影响的最新进展。我们还概述了只有通过在肿瘤微环境分析中应用高维单细胞技术和系统生物学方法才能解决的主要开放性问题。
