中国汉族人群中 和 的遗传多态性与肺结核的关系。
Genetic Polymorphisms of and in a Chinese Han Population with Pulmonary Tuberculosis.
机构信息
Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
出版信息
Biomed Res Int. 2018 May 14;2018:3010898. doi: 10.1155/2018/3010898. eCollection 2018.
BACKGROUND
The factors that predispose to pulmonary tuberculosis (PTB) are not fully understood. Previous studies have shown that cytokine gene polymorphisms were associated with PTB.
OBJECTIVES
In this study, we have investigated the relationship between , and polymorphisms and a predisposition to (MTB) infection and PTB.
METHODS
A total of 209 cases of PTB, 201 subjects with latent TB infection (LTBI), and 204 healthy controls (HCS) were included in this study. Logistic regression analyses under allelic, homozygous, and heterozygous models were used to calculate values, odds ratios (ORs), and 95% confidence intervals (CIs) for assessing the association between single nucleotide polymorphisms (SNPs) and disease risk, adjusting for sex and age. Genotyping was conducted using the improved multiplex ligase detection reaction (iMLDR) method.
RESULTS
When comparing PTB patients with LTBI subjects, significant associations with disease development were observed for SNPs of and . When comparing LTBI subjects with HCS, polymorphisms were significantly associated with LIBI. Haplotype analyses suggested that the CGG haplotype of was associated with an increased risk of PTB ( = 0.039, OR = 1.34, 95% CI: 1.01-1.76), while the TTGCG haplotype of was a protective factor against PTB ( = 0.039, OR = 0.66, 95% CI: 0.44-0.98).
CONCLUSION
Our study demonstrated that variants were related to LTBI and and variants were associated with PTB.
背景
导致肺结核（PTB）的因素尚未完全阐明。既往研究表明细胞因子基因多态性与 PTB 相关。
目的
本研究旨在探讨 、 及 基因多态性与结核分枝杆菌（MTB）感染及 PTB 易感性的关系。
方法
共纳入 209 例 PTB 患者、201 例潜伏性结核感染（LTBI）患者和 204 例健康对照者。采用等位基因、纯合子和杂合子模型的 logistic 回归分析，计算各单核苷酸多态性（SNP）与疾病风险的 值、比值比（OR）及其 95%置信区间（CI），以调整性别和年龄因素。采用改良多重连接酶检测反应（iMLDR）方法进行基因分型。
结果
与 LTBI 患者相比，PTB 患者的 及 基因 SNP 与疾病发展显著相关。与 HCS 相比，LTBI 患者的 基因 SNP 与 LTBI 显著相关。单体型分析提示 基因的 CGG 单体型与 PTB 风险增加相关（ = 0.039，OR = 1.34，95%CI：1.01-1.76），而 基因的 TTGCG 单体型是 PTB 的保护因素（ = 0.039，OR = 0.66，95%CI：0.44-0.98）。
结论
本研究表明 基因变体与 LTBI 相关， 及 基因变体与 PTB 相关。
Zotero 插件