PéREZ DE Isla Leopoldo Pérez, Moreno Fernando, Garcia Saez Jose Angel Garcia, Clavero Matias, Moreno Nuno, Aguado DE LA Rosa Carlos Aguado, DE Agustin Jose Alberto, Gomez DE Diego Jose Juan Gomez, Cobos Miguel Angel, Saltijeral Adriana, Macaya Carlos, Garcia-Fernandez Miguel Angel
Department of Cardiology, Clinical Hospital San Carlos, Health Research Institute, San Carlos, 28040 Madrid, Spain.
Department of Oncology, Clinical Hospital San Carlos, Health Research Institute, San Carlos, 28040 Madrid, Spain.
Mol Clin Oncol. 2015 Jul;3(4):820-824. doi: 10.3892/mco.2015.543. Epub 2015 Apr 9.
Certain chemotherapy drugs for breast cancer may induce cardiotoxicity and these patients should be echocardiographically monitored. The performance of a focused echocardiographic evaluation (echoscopy) at the patient's location by a non-cardiologist appears to be feasible. The aim of the present study was to assess the accuracy of echoscopy performed by medical oncologists in an outpatient clinic using hand-held echocardiography devices. The study cohort comprised consecutive unselected patients who attended an oncology outpatient clinic. Two medical oncologists attended a one-week training period, which included theoretical and practical teaching by an expert cardiologist. Every subject underwent two echo examinations. The first examination was performed by an oncologist using a hand-held echo device and the second was performed by a cardiologist using a 'premium' device. Out of the 101 enrolled patients, 32 were men (31.7%) and the mean age was 56.03±16.88 years. There was a good global agreement [intra-class correlation coefficient (ICC): 0.65 for left ventricular ejection fraction (LVEF)]. When the results were analyzed depending on the period of time when the echo studies were performed, a clear and short learning curve was observed: LVEF started at ICC=0.58 and increased to 0.66 and 0.77 in the second and third period, respectively. There were extremely few clinically significant differences and a learning curve was also evident. In conclusion, cardiac echoscopy performed by an oncologist with a hand-held device may lead to a similar clinical management as a study performed by an expert cardiologist with a 'premium' system in patients under chemotherapy following a short training period.
某些用于治疗乳腺癌的化疗药物可能会诱发心脏毒性,这些患者应接受超声心动图监测。由非心脏病专家在患者所在地进行聚焦超声心动图评估(超声检查)似乎是可行的。本研究的目的是评估肿瘤内科医生在门诊使用手持式超声心动图设备进行超声检查的准确性。研究队列包括连续入选的肿瘤门诊患者。两名肿瘤内科医生参加了为期一周的培训,其中包括由心脏病专家进行的理论和实践教学。每位受试者都接受了两次超声检查。第一次检查由肿瘤内科医生使用手持式超声设备进行,第二次检查由心脏病专家使用“高端”设备进行。在101名入选患者中,32名是男性(31.7%),平均年龄为56.03±16.88岁。总体一致性良好[组内相关系数(ICC):左心室射血分数(LVEF)为0.65]。当根据进行超声检查的时间段分析结果时,观察到一条清晰且较短的学习曲线:LVEF在第一个时间段时ICC = 0.58,在第二个和第三个时间段分别增至0.66和0.77。临床上的显著差异极少,学习曲线也很明显。总之,经过短期培训后,肿瘤内科医生使用手持式设备进行心脏超声检查可能会得出与心脏病专家使用“高端”系统进行的检查类似的临床管理结果,适用于接受化疗的患者。