患有中性粒细胞异常和反复感染的魏玛犬的体外免疫学特征。

In vitro immunologic features of Weimaraner dogs with neutrophil abnormalities and recurrent infections.

作者信息

Couto C G, Krakowka S, Johnson G, Ciekot P, Hill R, Lafrado L, Kociba G

机构信息

Department of Veterinary Clinical Sciences, Ohio State University, Columbus 43210.

出版信息

Vet Immunol Immunopathol. 1989 Nov 30;23(1-2):103-12. doi: 10.1016/0165-2427(89)90113-x.

DOI:10.1016/0165-2427(89)90113-x

PMID:2617844

Abstract

In vitro evaluation of cellular and humoral immunity in Weimaraner dogs with recurrent infections and abnormal neutrophil function revealed significantly lower serum immunoglobulin (Ig) G and M concentrations than control dogs. Lymphocyte blastogenesis in response to three different mitogens, interleukin-1 and -2 production, natural killer (NK) cell activity, and in vitro IgG and IgM production were similar to those of control dogs.

摘要

对患有反复感染和中性粒细胞功能异常的魏玛犬的细胞免疫和体液免疫进行的体外评估显示，其血清免疫球蛋白（Ig）G和M浓度显著低于对照犬。对三种不同有丝分裂原的淋巴细胞增殖反应、白细胞介素-1和-2的产生、自然杀伤（NK）细胞活性以及体外IgG和IgM的产生与对照犬相似。