Felsburg P J, Glickman L T, Jezyk P F
Clin Immunol Immunopathol. 1985 Sep;36(3):297-305. doi: 10.1016/0090-1229(85)90050-9.
This study documents the occurrence of selective IgA deficiency in the dog. This is a unique spontaneous animal model with clinical and immunologic findings similar to that of selective IgA deficiency in humans, the most common human primary immunodeficiency. The disease in the dog is characterized by chronic, recurrent respiratory infections and dermatitis, low concentrations of serum IgA, normal concentrations of serum IgG and IgM, normal T-cell function as measured by lymphocyte transformation tests, the presence of autoantibodies, and a defect in the maturation or terminal differentiation of IgA B cells into IgA-secreting plasma cells.
本研究记录了犬类中选择性IgA缺乏症的发生情况。这是一种独特的自发动物模型，其临床和免疫学表现与人类最常见的原发性免疫缺陷——选择性IgA缺乏症相似。犬类的这种疾病的特征为慢性复发性呼吸道感染和皮炎、血清IgA浓度低、血清IgG和IgM浓度正常、通过淋巴细胞转化试验测定的T细胞功能正常、存在自身抗体，以及IgA B细胞成熟或终末分化为分泌IgA的浆细胞存在缺陷。
