Qu Bao-Ge, Wang Hui, Liu Yuan-Xun, Jia Yi-Guo, Su Ji-Liang, Wang Zhong-Dong, Wang Ya-Fei, Han Xing-Hai, Pan Jin-Dun
Department of Gastroenterology, Taishan Hospital; Taishan Medical College, Taian, Shandong, China.
Medicine (Baltimore). 2015 Jul;94(28):e1087. doi: 10.1097/MD.0000000000001087.
Several studies have reported the relationship between alcoholic liver disease (ALD) and carotid intima-media thickness (CIMT). Few studies, however, have investigated the causes of CIMT thickening in patients with ALD. The authors explored the causes of CIMT thickening in patients with ALD. The authors enrolled 152 patients who were stratified into groups: nonthickening CIMT with ALD (group A); thickening CIMT with ALD (group B); nonthickening CIMT without ALD (group C); and thickening CIMT without ALD (group D). The CIMT was significantly different between patients with and without ALD (χ 2= 3.875, P = 0.049). The patients in groups A, B, and C were significantly younger than group D (P = 0.001, 0.036, and 0.001, respectively). The body mass indexes (BMI) in groups A and B were significantly higher than in group C (P = 0.000 and 0.007, respectively). The blood glucose levels in groups B and D were significantly higher than in group C (P = 0.016 and 0.018, respectively). The blood uric acid levels in group B were significantly higher than in groups A, C, and D (P = 0.009, 0.000, and 0.003, respectively). The blood uric acid in group A was significantly higher than in group C (P = 0.002). The serum total cholesterol (TC) levels of patients in group B were significantly higher than in groups A and C (P = 0.027 and 0.000, respectively) and the serum TC level in group A was significantly higher than in group C (P = 0.048). The serum triglyceride (TG) levels in groups A and B were significantly higher than in group C (P = 0.027 and 0.000, respectively). The serum of very low-density lipoprotein (VLDL) levels in group B were significantly higher than in group C (P = 0.000). Although a comparison of the low-density lipoprotein (LDL) and high-density lipoprotein (HDL) serum levels among the 4 groups indicated no changes. The serum LDL levels in group B were significantly higher than in group A (P = 0.008). No significant differences were observed among the groups with respect to serum homocysteine, C-reactive protein (CRP), interleukin-6 (IL-6), malondialdehyde (MDA), superoxide dismutase (SOD), soluble OX40 ligand (sOX40L), or heat shock protein (HSP) 60 or 70. Alcoholic liver disease may result in CIMT thickening. Carotid intima-media thickness is associated with age and metabolic factors in patients with ALD. In addition, ALD might promote the premature occurrence of CIMT thickening. The thickening of carotid artery intima thickness, however, is not associated with cytokine profiles, oxidative balance, or immune responses in patients with ALD.
多项研究报告了酒精性肝病（ALD）与颈动脉内膜中层厚度（CIMT）之间的关系。然而，很少有研究调查ALD患者CIMT增厚的原因。作者探讨了ALD患者CIMT增厚的原因。作者招募了152名患者，并将其分为以下几组：ALD患者CIMT未增厚组（A组）；ALD患者CIMT增厚组（B组）；非ALD患者CIMT未增厚组（C组）；非ALD患者CIMT增厚组（D组）。有ALD和无ALD患者之间的CIMT存在显著差异（χ² = 3.875，P = 0.049）。A组、B组和C组患者的年龄显著低于D组（分别为P = 0.001、0.036和0.001）。A组和B组的体重指数（BMI）显著高于C组（分别为P = 0.000和0.007）。B组和D组的血糖水平显著高于C组（分别为P = 0.016和0.018）。B组的血尿酸水平显著高于A组、C组和D组（分别为P = 0.009、0.000和0.003）。A组的血尿酸显著高于C组（P = 0.002）。B组患者的血清总胆固醇（TC）水平显著高于A组和C组（分别为P = 0.027和0.000），且A组的血清TC水平显著高于C组（P = 0.048）。A组和B组的血清甘油三酯（TG）水平显著高于C组（分别为P = 0.027和0.000）。B组的血清极低密度脂蛋白（VLDL）水平显著高于C组（P = 0.000）。尽管对4组患者的低密度脂蛋白（LDL）和高密度脂蛋白（HDL）血清水平进行比较未发现变化。B组的血清LDL水平显著高于A组（P = 0.008）。在血清同型半胱氨酸、C反应蛋白（CRP）、白细胞介素-6（IL-6）、丙二醛（MDA）、超氧化物歧化酶（SOD）、可溶性OX40配体（sOX40L）或热休克蛋白（HSP）60或70方面，各组之间未观察到显著差异。酒精性肝病可能导致CIMT增厚。在ALD患者中，颈动脉内膜中层厚度与年龄和代谢因素有关。此外，ALD可能会促进CIMT增厚的过早发生。然而，在ALD患者中，颈动脉内膜厚度的增厚与细胞因子谱、氧化平衡或免疫反应无关。
