Lee Elin, Sanjay Srinivasan
From the *Department of Ophthalmology and Visual Sciences, Khoo Teck Puat Hospital; †Ministry of Health Holdings; and ‡Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
Asia Pac J Ophthalmol (Phila). 2015 Sep-Oct;4(5):273-8. doi: 10.1097/APO.0000000000000096.
The aim of this study was to report the clinical features of optic disc melanocytoma (ODMC).
This study was a retrospective case series.
Five patients (6 eyes) with ODMC followed up over a mean duration of 3 years (range, 4-61 months) were included in this series.
The mean age of diagnosis was 55.2 years with Chinese female predominance. Four of 6 ODMCs were unilateral with predominance to the left side. Four patients had visual acuity of 6/9 or better at presentation, and all ODMCs were discovered incidentally. All ODMCs were black, with an average size of 0.8 disc diameter and partially covering the optic disc. Five of 6 ODMCs were inferiorly located and involved adjacent choroid and retina. Three of 6 ODMCs had ill-defined borders. Fundus fluorescein angiogram findings in 1 patient showed blocked fluorescence due to pigments. No loss of visual acuity of 2 or more Snellen lines, ODMC enlargement, or malignant transformation were noted in any patients during follow-up. There were no local complications. Ocular and systemic associations were not seen.
Our case series did not show any features of progression during our follow-up. Annual fundoscopic examinations are still important to detect enlargement and malignant transformation.
本研究旨在报告视盘黑色素细胞瘤（ODMC）的临床特征。
本研究为回顾性病例系列研究。
本系列纳入了5例（6只眼）ODMC患者，平均随访时间为3年（范围4 - 61个月）。
诊断时的平均年龄为55.2岁，以中国女性为主。6只ODMC眼中有4只为单侧，以左侧居多。4例患者就诊时视力为6/9或更好，所有ODMC均为偶然发现。所有ODMC均为黑色，平均大小为0.8个视盘直径，部分覆盖视盘。6只ODMC眼中有5只位于下方，累及相邻的脉络膜和视网膜。6只ODMC眼中有3只边界不清。1例患者的眼底荧光血管造影结果显示因色素导致荧光遮挡。随访期间，所有患者均未出现视力下降2行及以上、ODMC增大或恶变。无局部并发症。未发现眼部和全身相关病变。
我们的病例系列在随访期间未显示任何进展特征。每年进行眼底检查对于发现增大和恶变仍然很重要。
