Ørbo Marte, Aslaksen Per M, Larsby Kristina, Schäfer Christoph, Tande Pål M, Vangberg Torgil R, Anke Audny
Department of Rehabilitation, Division of Rehabilitation Services, University hospital of North Norway, 9038 Tromsø, Norway.
J Rehabil Med. 2015 Oct 5;47(9):860-6. doi: 10.2340/16501977-1998.
For survivors of out-of-hospital cardiac arrest (OHCA) with good outcomes, it is not known whether and how health-related quality of life is affected by the cognitive impairments frequently observed in these patients. This study explores how neuropsychological tests of memory, exe-cutive and psychomotor functioning relate to the physical and mental aspects of health-related quality of life in functionally independent and community dwelling OHCA survivors discharged early from hospital.
The study included 42 adult survivors (mean age 62 years, 38 males). Health-related quality of life was measured approximately 3 months post-OHCA with the Medical Outcome Study Short Form 36 (SF-36). Cognition was measured with established neuropsychological tests. Regression analyses were used to examine associations between neuropsychological domains and physical and mental health-related quality of life, respectively, when controlling for age, education and length of coma.
The physical, but not the mental, component of the SF-36 was significantly worse than Norwegian population data. Neuropsychological tests showed frequent impairments most often in the memory domain. Worse psychomotor functioning was associated with worse physical health-related quality of life, whereas worse memory performance was associated with worse mental health-related quality of life.
The cognitive impairments frequently reported in OHCA survivors with good outcomes may compromise health-related quality of life. Cognitive functioning should be addressed even in survivors with rapid recovery.
对于院外心脏骤停（OHCA）后预后良好的幸存者，尚不清楚这些患者中经常观察到的认知障碍是否以及如何影响与健康相关的生活质量。本研究探讨了记忆、执行和心理运动功能的神经心理学测试如何与功能独立且居住在社区的OHCA幸存者早期出院后与健康相关生活质量的身体和心理方面相关联。
该研究纳入了42名成年幸存者（平均年龄62岁，38名男性）。在OHCA后约3个月，使用医学结局研究简明健康调查问卷（SF - 36）测量与健康相关的生活质量。使用既定的神经心理学测试测量认知。在控制年龄、教育程度和昏迷时长的情况下，分别使用回归分析来检验神经心理学领域与身体和心理健康相关生活质量之间的关联。
SF - 36的身体部分而非心理部分显著差于挪威人群数据。神经心理学测试显示，记忆领域最常出现频繁的损伤。较差的心理运动功能与较差的身体健康相关生活质量相关，而较差的记忆表现与较差的心理健康相关生活质量相关。
在OHCA后预后良好的幸存者中经常报告的认知障碍可能会损害与健康相关的生活质量。即使是恢复迅速的幸存者，也应关注认知功能。
