Heimburg Katarina, Cronberg Tobias, Tornberg Åsa B, Ullén Susann, Friberg Hans, Nielsen Niklas, Hassager Christian, Horn Janneke, Kjærgaard Jesper, Kuiper Michael, Rylander Christian, Wise Matt P, Lilja Gisela
Lund University, Skane University Hospital, Department of Clinical Sciences Lund, Neurology, Lund, Sweden.
Lund University, Department of Health Sciences, Lund, Sweden.
Resusc Plus. 2022 Jul 19;11:100275. doi: 10.1016/j.resplu.2022.100275. eCollection 2022 Sep.
Self-reported limitations in physical function are common 6 months after out-of-hospital cardiac arrest.
Out-of-hospital cardiac arrest (OHCA) survivors generally report good health-related quality of life, but physical aspects of health seem more affected than other domains. Limitations in physical function after surviving OHCA have received little attention.
To describe physical function 6 months after OHCA and compare it with a group of ST elevation myocardial infarction (STEMI) controls, matched for country, age, sex and time of the cardiac event. A second aim was to explore variables potentially associated with self-reported limitations in physical function in OHCA survivors.
A cross-sectional sub-study of the Targeted Temperature Management at 33 °C versus 36 °C (TTM) trial with a follow-up 6 months post-event. Physical function was the main outcome assessed with the self-reported Physical Functioning-10 items scale (PF-10). PF-10 is presented as T-scores (0-100), where 50 represents the norm mean. Scores <47 at a group level, or <45 at an individual level indicate limitations in physical function.
287 OHCA survivors and 119 STEMI controls participated. Self-reported physical function by PF-10 was significantly lower for OHCA survivors compared to STEMI controls (mean 46.0, SD 11.2 vs. 48.8, SD 9.0, = 0.025). 38% of OHCA survivors compared to 26% of STEMI controls reported limitations in physical function at an individual level ( = 0.022). The most predictive variables for self-reported limitations in physical function in OHCA survivors were older age, female sex, cognitive impairment, and symptoms of anxiety and depression after 6 months.
Self-reported limitations in physical function are more common in OHCA survivors compared to STEMI controls.
ClinicalTrials.gov Identifier: NCT01946932.
院外心脏骤停6个月后自我报告的身体功能受限情况很常见。
院外心脏骤停（OHCA）幸存者通常报告与健康相关的生活质量良好，但健康的身体方面似乎比其他领域受到的影响更大。OHCA存活后身体功能受限的情况很少受到关注。
描述OHCA后6个月的身体功能，并将其与一组ST段抬高型心肌梗死（STEMI）对照者进行比较，这些对照者在国家、年龄、性别和心脏事件发生时间方面进行了匹配。第二个目的是探讨与OHCA幸存者自我报告的身体功能受限可能相关的变量。
对33°C与36°C目标温度管理（TTM）试验进行横断面子研究，在事件发生后6个月进行随访。身体功能是使用自我报告的10项身体功能量表（PF-10）评估的主要结局。PF-10以T分数（0-100）表示，其中50代表正常均值。在组水平上得分<47，或在个体水平上得分<45表明身体功能受限。
287名OHCA幸存者和119名STEMI对照者参与。与STEMI对照者相比，OHCA幸存者通过PF-10自我报告的身体功能显著更低（均值46.0，标准差11.2对48.8，标准差9.0，P = 0.025）。与26%的STEMI对照者相比，38%的OHCA幸存者报告在个体水平上身体功能受限（P = 0.022）。OHCA幸存者自我报告的身体功能受限的最具预测性的变量是年龄较大、女性、认知障碍以及6个月后的焦虑和抑郁症状。
与STEMI对照者相比，OHCA幸存者自我报告的身体功能受限情况更常见。
ClinicalTrials.gov标识符：NCT01946932。
