Khalid Nauman, Chhabra Lovely, Kluger Jeffrey
J Ayub Med Coll Abbottabad. 2015 Jan-Mar;27(1):228-31.
Brugada syndrome (BS) is characterized by a typical electrocardiographic (ECG) pattern in the right precordial leads and a predisposition to develop ventricular arrhythmias. Mutations in a subunit of cardiac sodium channel (SCN5A) have been linked to BS. Experimental studies in the literature suggest that this dysfunction of the mutated channel can be temperature sensitive. Several antiarrhythmics have been used in the management of BS but Implantable Cardioverter Defibrillators (ICD) remains the only effective treatment. We herewith present the case report of a 62-year-old man who developed a type-2 Brugada ECG phenotype in a febrile state with complete resolution once the fever subsided.
布加综合征(BS)的特征是右胸前导联出现典型的心电图(ECG)模式,并易发生室性心律失常。心脏钠通道(SCN5A)一个亚基的突变与布加综合征有关。文献中的实验研究表明,突变通道的这种功能障碍可能对温度敏感。几种抗心律失常药物已用于布加综合征的治疗,但植入式心脏复律除颤器(ICD)仍然是唯一有效的治疗方法。我们在此报告一例62岁男性病例,该患者在发热状态下出现2型布加综合征心电图表型,发热消退后完全缓解。