Ohbatake Yoshinao, Makino Isamu, Kitagawa Hirohisa, Nakanuma Shinichi, Hayashi Hironori, Nakagawara Hisatoshi, Miyashita Tomoharu, Tajima Hidehiro, Takamura Hiroyuki, Ninomiya Itasu, Fushida Sachio, Fujimura Takashi, Ohta Tetsuo
Department of Gastroenterologic Surgery, Graduate School of Medical Science, Kanazawa University, 13-1 Takaramachi, Kanazawa, Ishikawa, 920-8641, Japan,
Clin J Gastroenterol. 2014 Jun;7(3):265-70. doi: 10.1007/s12328-014-0480-8. Epub 2014 Apr 3.
Pancreatic schwannoma is a very rare tumor that tends to be confused with other pancreatic tumors preoperatively. We report a case of schwannoma of the pancreatic head. A 40-year-old woman was admitted to our hospital for treatment of a pancreatic tumor which was found by medical checkup. It was a well-defined solid tumor exhibiting heterogeneous enhancement with some necrotic foci on contrast-enhanced computed tomography (CT) and on magnetic resonance imaging (MRI). Angiography and CT during arteriography revealed the main feeding arteries of the tumor to be the posterior and anterior superior pancreaticoduodenal arteries. Fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) showed accumulation of FDG in the tumor with a maximum standardized uptake value of 3.6. We diagnosed a solid pseudopapillary neoplasm or a pancreatic neuroendocrine tumor preoperatively and performed pylorus-preserving pancreaticoduodenectomy. The tumor had well a well-defined capsule and was composed of a large solid portion containing spindle cells and a smaller hemorrhagic portion containing hypocellular stroma, and diagnosed as pancreatic schwannoma by immunohistochemistry. In this case, CT during arteriography was useful in determining the origin of the tumor. MRI reflected the pathological features of the tumor. The most important finding was that FDG-PET showed abnormal accumulation of FDG in the benign pancreatic schwannoma.
胰腺神经鞘瘤是一种非常罕见的肿瘤,术前往往容易与其他胰腺肿瘤混淆。我们报告一例胰头神经鞘瘤。一名40岁女性因体检发现胰腺肿瘤入院治疗。在对比增强计算机断层扫描(CT)和磁共振成像(MRI)上,这是一个边界清晰的实性肿瘤,表现为不均匀强化,伴有一些坏死灶。血管造影和动脉造影CT显示肿瘤的主要供血动脉为胰十二指肠后动脉和胰十二指肠上前动脉。氟-18氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描(FDG-PET/CT)显示肿瘤内有FDG聚集,最大标准化摄取值为3.6。我们术前诊断为实性假乳头状肿瘤或胰腺神经内分泌肿瘤,并进行了保留幽门的胰十二指肠切除术。肿瘤有完整的包膜,由一个含有梭形细胞的大实性部分和一个含有细胞稀少基质的较小出血部分组成,免疫组织化学诊断为胰腺神经鞘瘤。在本例中,动脉造影CT有助于确定肿瘤的起源。MRI反映了肿瘤的病理特征。最重要的发现是FDG-PET显示良性胰腺神经鞘瘤中有FDG异常聚集。