Hamada Kenichiro, Tomita Yasuhiko, Qiu Ying, Tomoeda Miki, Ueda Takafumi, Tamai Noriyuki, Hashimoto Nobuyuki, Yoshikawa Hideki, Aozasa Katsuyuki, Hatazawa Jun
Department of Orthopedic Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan.
Skeletal Radiol. 2009 Mar;38(3):261-6. doi: 10.1007/s00256-008-0612-7. Epub 2008 Dec 17.
In order to clarify the increased 2-deoxy-2-fluoro-(18)F-D: -glucopyranose ((18)F-FDG) accumulation in schwannoma by positron emission tomography (PET) analysis, immunohistochemical analysis for the factors involved in glucose transportation and vascular formation was performed.
Twenty-six patients with schwannoma (13 men and 13 women) with ages ranging from 27 to 75 years, who received whole body (18)F-FDG PET scan, were enrolled for the present study. The retention index (RI) was calculated by dividing the increase in the standardized uptake value (SUVmax) at the delayed scan by the SUVmax in the early scan. SUVmax and RI were compared with the histologic variables, including the expression of glucose transporters 1 and 3, hexokinase II, vascular endothelial growth factor/vascular permeability factor (VEGF/VPF), and microvascular density shown by CD31 immunohistochemistry.
Mean SUVmax values in the early and delayed scans were 2.64 +/- 1.47 and 2.71 +/- 1.57 (mean +/- SD), respectively. RI was -2.5 +/- 21 (percentage). SUVmax showed a positive correlation with the tumor size (tumor size <5 cm, 2.06 +/- 0.72; >5 cm, 3.95 +/- 1.89; p < 0.05) and the microvascular density (negative density, 2.16 +/- 1.12; positive density, 3.56 +/- 1.67; p < 0.05). RI correlated with VEGF/VPF expression in the tumors (negative expression, -11 +/- 6.1; positive expression, 13 +/- 8.1; p < 0.05). Other factors showed no correlation with SUVmax or RI.
Microvascular density and vascular permeability of the tumor are suggested to affect the enhanced (18)F-FDG accumulation in schwannoma.
为了通过正电子发射断层扫描（PET）分析阐明神经鞘瘤中2-脱氧-2-氟-（18）F-D-葡萄糖（（18）F-FDG）摄取增加的情况，对参与葡萄糖转运和血管形成的相关因素进行了免疫组织化学分析。
本研究纳入了26例年龄在27至75岁之间的神经鞘瘤患者（13例男性和13例女性），这些患者均接受了全身（18）F-FDG PET扫描。保留指数（RI）通过延迟扫描时标准化摄取值（SUVmax）的增加量除以早期扫描时的SUVmax来计算。将SUVmax和RI与组织学变量进行比较，这些组织学变量包括葡萄糖转运蛋白1和3、己糖激酶II、血管内皮生长因子/血管通透因子（VEGF/VPF）的表达以及通过CD31免疫组织化学显示的微血管密度。
早期和延迟扫描时的平均SUVmax值分别为2.64±1.47和2.71±1.57（平均值±标准差）。RI为-2.5±21（百分比）。SUVmax与肿瘤大小呈正相关（肿瘤大小<5 cm，2.06±0.72；>5 cm，3.95±1.89；p<0.05）以及与微血管密度呈正相关（微血管密度阴性，2.16±1.12；微血管密度阳性，3.56±1.67；p<0.05）。RI与肿瘤中VEGF/VPF的表达相关（阴性表达，-11±6.1；阳性表达，13±8.1；p<0.05）。其他因素与SUVmax或RI均无相关性。
提示肿瘤的微血管密度和血管通透性会影响神经鞘瘤中增强的（18）F-FDG摄取。
