小儿单纯疱疹病毒性脑炎合并N-甲基-D-天冬氨酸受体抗体脑炎
Pediatric Herpes Simplex Virus Encephalitis Complicated by N-Methyl-D-aspartate Receptor Antibody Encephalitis.
作者信息
Bamford Alasdair, Crowe Belinda H A, Hacohen Yael, Lin Jean-Pierre, Clarke Antonia, Tudor-Williams Gareth, Sancho-Shimizu Vanessa, Vincent Angela, Lim Ming, Pullaperuma Sunil P
机构信息
Department of Paediatric Infectious Diseases ; Section of Paediatrics, Imperial College, London, United Kingdom.
Paediatric Neurodisability Service, St Mary's Hospital, Imperial College Healthcare NHS Trust, London, United Kingdom.
出版信息
J Pediatric Infect Dis Soc. 2015 Jun;4(2):e17-21. doi: 10.1093/jpids/piu054. Epub 2014 Jun 12.
Abstract
N-methyl-D-aspartate receptor antibodies (NMDAR-Abs) can contribute to neurological relapse after herpes simplex virus encephalitis (HSE). We describe a child with NMDAR-Ab encephalitis after HSE, which was recognized and treated early. We discuss the case in the context of existing reports, and we propose a modified immunotherapy strategy to minimize risk of viral reactivation.
摘要
N-甲基-D-天冬氨酸受体抗体（NMDAR-Abs）可导致单纯疱疹病毒性脑炎（HSE）后出现神经功能复发。我们描述了一名HSE后发生NMDAR-Ab脑炎的儿童，该病例得到了早期诊断和治疗。我们结合现有报告对该病例进行讨论，并提出一种改良的免疫治疗策略，以尽量降低病毒再激活的风险。
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