单纯疱疹病毒性脑炎是脑自身免疫的触发因素。
Herpes simplex virus encephalitis is a trigger of brain autoimmunity.
机构信息
August Pi i Sunyer Biomedical Research Institute (IDIBAPS), Neurology Service, Hospital Clinic, University of Barcelona, Barcelona, Spain; Department of Pediatric Neurology, Materno-Infantil Vall d'Hebron Hospital, Autonomous University of Barcelona, Barcelona, Spain.
出版信息
Ann Neurol. 2014 Feb;75(2):317-23. doi: 10.1002/ana.24083. Epub 2014 Feb 25.
Abstract
In 5 prospectively diagnosed patients with relapsing post-herpes simplex encephalitis (HSE), N-methyl-D-aspartate receptor (NMDAR) antibodies were identified. Antibody synthesis started 1 to 4 weeks after HSE, preceding the neurological relapse. Three of 5 patients improved postimmunotherapy, 1 spontaneously, and 1 has started to improve. Two additional patients with NMDAR antibodies, 9 with unknown neuronal surface antibodies, and 1 with NMDAR and unknown antibodies, were identified during retrospective assessment of 34 HSE patients; the frequency of autoantibodies increased over time (serum, p=0.004; cerebrospinal fluid, p=0.04). The 3 retrospectively identified NMDAR antibody-positive patients also had evidence of relapsing post-HSE. Overall, these findings indicate that HSE triggers NMDAR antibodies and potentially other brain autoimmunity.
摘要
在 5 例复发性单纯疱疹后脑炎（HSE）患者中，发现了 N-甲基-D-天冬氨酸受体（NMDAR）抗体。抗体合成始于 HSE 后 1 至 4 周，早于神经复发。5 例患者中有 3 例在免疫治疗后改善，1 例自发改善，1 例开始改善。在对 34 例 HSE 患者进行回顾性评估期间，还发现了另外 2 例 NMDAR 抗体阳性患者、9 例未知神经元表面抗体阳性患者和 1 例 NMDAR 和未知抗体阳性患者；自身抗体的频率随时间增加（血清，p=0.004；脑脊液，p=0.04）。这 3 例回顾性发现的 NMDAR 抗体阳性患者也有复发性 HSE 后证据。总的来说，这些发现表明 HSE 引发了 NMDAR 抗体，并可能引发其他脑自身免疫。
相似文献
1
Herpes simplex virus encephalitis is a trigger of brain autoimmunity.单纯疱疹病毒性脑炎是脑自身免疫的触发因素。
Ann Neurol. 2014 Feb;75(2):317-23. doi: 10.1002/ana.24083. Epub 2014 Feb 25.
2
Cerebrospinal fluid cyto-/chemokine profile during acute herpes simplex virus induced anti-N-methyl-d-aspartate receptor encephalitis and in chronic neurological sequelae.急性单纯疱疹病毒诱导的抗N-甲基-D-天冬氨酸受体脑炎及慢性神经后遗症期间的脑脊液细胞因子/趋化因子谱
Dev Med Child Neurol. 2017 Aug;59(8):806-814. doi: 10.1111/dmcn.13431. Epub 2017 Apr 25.
3
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.单纯疱疹脑炎中的 N-甲基-D-天冬氨酸受体抗体。
Ann Neurol. 2012 Dec;72(6):902-11. doi: 10.1002/ana.23689.
4
Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor.单纯疱疹病毒性脑炎复发伴舞蹈症与抗 N-甲基-D-天冬氨酸受体或多巴胺-2 受体自身抗体有关。
Mov Disord. 2014 Jan;29(1):117-22. doi: 10.1002/mds.25623. Epub 2013 Oct 1.
5
N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.单纯疱疹病毒脑炎后神经复发时 N-甲基-D-天冬氨酸受体抗体
Mov Disord. 2014 Jan;29(1):90-6. doi: 10.1002/mds.25626. Epub 2013 Sep 6.
6
N-methyl-d-aspartate receptor autoimmunity affects cognitive performance in herpes simplex encephalitis.N-甲基-D-天冬氨酸受体自身免疫会影响单纯疱疹脑炎患者的认知表现。
Clin Microbiol Infect. 2016 Nov;22(11):934-940. doi: 10.1016/j.cmi.2016.07.028. Epub 2016 Aug 3.
7
Frequency, symptoms, risk factors, and outcomes of autoimmune encephalitis after herpes simplex encephalitis: a prospective observational study and retrospective analysis.单纯疱疹脑炎后自身免疫性脑炎的频率、症状、危险因素和结局：一项前瞻性观察研究和回顾性分析。
Lancet Neurol. 2018 Sep;17(9):760-772. doi: 10.1016/S1474-4422(18)30244-8. Epub 2018 Jul 23.
8
Cerebrospinal fluid biomarkers of brain injury, inflammation and synaptic autoimmunity predict long-term neurocognitive outcome in herpes simplex encephalitis.脑损伤、炎症和突触自身免疫的脑脊液生物标志物可预测单纯疱疹脑炎的长期神经认知结局。
Clin Microbiol Infect. 2021 Aug;27(8):1131-1136. doi: 10.1016/j.cmi.2020.09.031. Epub 2020 Sep 23.
9
Cerebrospinal Fluid Extracellular Vesicles with Distinct Properties in Autoimmune Encephalitis and Herpes Simplex Encephalitis.自身免疫性脑炎和单纯疱疹病毒性脑炎中具有不同特性的脑脊液细胞外囊泡。
Mol Neurobiol. 2022 Apr;59(4):2441-2455. doi: 10.1007/s12035-021-02705-2. Epub 2022 Jan 27.
10
Absent anti-N-methyl-D-aspartate receptor NR1a antibodies in herpes simplex virus encephalitis and varicella zoster virus infections.单纯疱疹病毒性脑炎和水痘-带状疱疹病毒感染中抗N-甲基-D-天冬氨酸受体NR1a抗体缺失。
Int J Neurosci. 2017 Feb;127(2):109-117. doi: 10.3109/00207454.2016.1147447. Epub 2016 Feb 17.
引用本文的文献
1
Comorbidities and Their Influence on Outcomes and Infectious Complications in Autoimmune Encephalitis: A Multicenter Cohort Study.自身免疫性脑炎的合并症及其对结局和感染并发症的影响：一项多中心队列研究
Neurol Neuroimmunol Neuroinflamm. 2025 Sep;12(5):e200434. doi: 10.1212/NXI.0000000000200434. Epub 2025 Jul 7.
2
Autoantibodies Against Collapsin Response Mediator Proteins Associated With Encephalopathy/Myelopathy: A Single-Center Retrospective Study.与脑病/脊髓病相关的塌陷反应介导蛋白自身抗体：一项单中心回顾性研究。
CNS Neurosci Ther. 2025 Jun;31(6):e70423. doi: 10.1111/cns.70423.
3
Acute neuronal cell death and neuroinflammation per se do not trigger secondary autoimmune encephalitis in mice.急性神经元细胞死亡和神经炎症本身并不会引发小鼠的继发性自身免疫性脑炎。
Sci Rep. 2025 Jun 27;15(1):20337. doi: 10.1038/s41598-025-08035-w.
4
Case Report: Anti-NMDAR encephalitis associated with neurobrucellosis: causality or coexistence?病例报告：抗NMDAR脑炎与神经型布鲁氏菌病：因果关系还是并存？
Front Immunol. 2025 May 15;16:1536740. doi: 10.3389/fimmu.2025.1536740. eCollection 2025.
5
Neural autoantibodies in psychiatric disorders are associated with antibodies against viral pathogens: a retrospective study of 619 patients.精神疾病中的神经自身抗体与抗病毒病原体抗体有关：一项对619名患者的回顾性研究
J Neural Transm (Vienna). 2025 May 17. doi: 10.1007/s00702-025-02943-x.
6
Long-Term Cognitive, Functional, and Patient-Reported Outcomes in Patients With Anti-NMDAR Encephalitis.抗 NMDAR 脑炎患者的长期认知、功能和患者报告结局。
Neurology. 2024 Dec 24;103(12):e210109. doi: 10.1212/WNL.0000000000210109. Epub 2024 Nov 20.
7
Comparison of B Cell Variable Region Gene Segment Characteristics in Neuro-autoantibodies.神经自身抗体中 B 细胞可变区基因片段特征的比较。
Immunohorizons. 2024 Oct 1;8(10):740-748. doi: 10.4049/immunohorizons.2400037.
8
HSV-2 Manipulates Autophagy through Interferon Pathway: A Strategy for Viral Survival.单纯疱疹病毒 2 型通过干扰素途径操纵自噬：病毒生存的一种策略。
Viruses. 2024 Aug 29;16(9):1383. doi: 10.3390/v16091383.
9
Post-Herpetic Anti-NMDAR Encephalitis in Denmark: Current Status and Future Challenges.丹麦的疱疹后抗NMDAR脑炎：现状与未来挑战
Biomedicines. 2024 Aug 27;12(9):1953. doi: 10.3390/biomedicines12091953.
10
From Psychosis to Recovery: A Case Report of N-Methyl-D-Aspartate (NMDA) Receptor Encephalitis.从精神病到康复：一例N-甲基-D-天冬氨酸（NMDA）受体脑炎病例报告
Cureus. 2024 Aug 20;16(8):e67272. doi: 10.7759/cureus.67272. eCollection 2024 Aug.
本文引用的文献
1
Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-Methyl-D-aspartate receptor or dopamine-2 receptor.单纯疱疹病毒性脑炎复发伴舞蹈症与抗 N-甲基-D-天冬氨酸受体或多巴胺-2 受体自身抗体有关。
Mov Disord. 2014 Jan;29(1):117-22. doi: 10.1002/mds.25623. Epub 2013 Oct 1.
2
Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report.单纯疱疹病毒 1 型脑炎可引发抗 N-甲基-D-天冬氨酸受体脑炎：病例报告。
Neurology. 2013 Oct 29;81(18):1637-9. doi: 10.1212/WNL.0b013e3182a9f531. Epub 2013 Oct 2.
3
N-methyl-D-aspartate receptor antibodies in post-herpes simplex virus encephalitis neurological relapse.单纯疱疹病毒脑炎后神经复发时 N-甲基-D-天冬氨酸受体抗体
Mov Disord. 2014 Jan;29(1):90-6. doi: 10.1002/mds.25626. Epub 2013 Sep 6.
4
Pediatric herpes simplex virus encephalitis: a retrospective multicenter experience.小儿单纯疱疹病毒性脑炎：一项回顾性多中心研究经验
J Child Neurol. 2013 Mar;28(3):321-31. doi: 10.1177/0883073812471428. Epub 2013 Jan 16.
5
Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study.抗 NMDA 受体脑炎患者的长期预后的治疗和预后因素：一项观察性队列研究。
Lancet Neurol. 2013 Feb;12(2):157-65. doi: 10.1016/S1474-4422(12)70310-1. Epub 2013 Jan 3.
6
N-methyl-D-aspartate receptor antibodies in herpes simplex encephalitis.单纯疱疹脑炎中的 N-甲基-D-天冬氨酸受体抗体。
Ann Neurol. 2012 Dec;72(6):902-11. doi: 10.1002/ana.23689.
7
Encephalitis and antibodies to dipeptidyl-peptidase-like protein-6, a subunit of Kv4.2 potassium channels.脑炎与二肽基肽酶样蛋白-6 抗体，一种 Kv4.2 钾通道亚单位。
Ann Neurol. 2013 Jan;73(1):120-8. doi: 10.1002/ana.23756. Epub 2012 Dec 7.
8
Pediatric anti-N-methyl-D-aspartate receptor encephalitis-clinical analysis and novel findings in a series of 20 patients.儿科抗 N-甲基-D-天冬氨酸受体脑炎：20 例患者的临床分析及新发现。
J Pediatr. 2013 Apr;162(4):850-856.e2. doi: 10.1016/j.jpeds.2012.10.011. Epub 2012 Nov 16.
9
Atypical manifestations and poor outcome of herpes simplex encephalitis in the immunocompromised.免疫功能低下者单纯疱疹脑炎的非典型表现和不良预后。
Neurology. 2012 Nov 20;79(21):2125-32. doi: 10.1212/WNL.0b013e3182752ceb. Epub 2012 Nov 7.
10
Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.抗 NMDA 受体脑炎抗体结合依赖于 GluN1 氨基末端结构域内一个小区域的氨基酸同一性。
J Neurosci. 2012 Aug 8;32(32):11082-94. doi: 10.1523/JNEUROSCI.0064-12.2012.
Zotero 插件