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先天性心脏病患者子宫动静脉畸形采用促性腺激素释放激素激动剂的保守治疗

Conservative therapy with a gonadotropin-releasing hormone agonist for a uterine arteriovenous malformation in a patient with congenital heart disease.

作者信息

Katano Kinue, Takeda Yutaka, Sugiura-Ogasawara Mayumi

机构信息

Department of Obstetrics & Gynecology, Nagoya City University, Graduate School of Medical Sciences Nagoya, Japan.

Department of Cardiology, Nagoya City University, Graduate School of Medical Sciences Nagoya, Japan.

出版信息

Clin Case Rep. 2015 Jun;3(6):479-82. doi: 10.1002/ccr3.233. Epub 2015 Apr 29.

DOI:10.1002/ccr3.233
PMID:26185652
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4498866/
Abstract

Uterine arteriovenous malformation (AVM) is rare but it can cause life-threatening genital bleeding. Conservative therapy with GnRHa can be a useful option for treating a uterine AVM presenting with a congenital heart disease shunt in hemodynamically stable patients.

摘要

子宫动静脉畸形（AVM）较为罕见，但可导致危及生命的生殖器出血。对于血流动力学稳定且患有先天性心脏病分流的子宫AVM患者，使用促性腺激素释放激素激动剂（GnRHa）进行保守治疗可能是一种有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/38d7ecf2443a/ccr30003-0479-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/e9d940890bdc/ccr30003-0479-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/81e242498b36/ccr30003-0479-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/69ecc83f6441/ccr30003-0479-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/38d7ecf2443a/ccr30003-0479-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/e9d940890bdc/ccr30003-0479-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/81e242498b36/ccr30003-0479-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/69ecc83f6441/ccr30003-0479-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f7df/4498866/38d7ecf2443a/ccr30003-0479-f4.jpg

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VEGF-A regulated by progesterone governs uterine angiogenesis and vascular remodelling during pregnancy.孕激素调控的 VEGF-A 调节妊娠子宫血管生成和血管重塑。
EMBO Mol Med. 2013 Sep;5(9):1415-30. doi: 10.1002/emmm.201302618. Epub 2013 Aug 2.
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Uterine arteriovenous malformations induced after diagnostic curettage: a systematic review.诊断性刮宫术后引起的子宫动静脉畸形：系统评价。
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3
Complications of embolization.栓塞的并发症。
剖宫产术后获得性子宫动静脉畸形的经动脉栓塞治疗：病例系列
Int J Reprod Biomed. 2019 Mar 19;17(2):135-42. doi: 10.18502/ijrm.v17i2.3991. eCollection 2019 Feb.
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Resolution of uterine arteriovenous malformation and successful pregnancy after treatment with a gonadotropin-releasing hormone agonist.经促性腺激素释放激素激动剂治疗后子宫动静脉畸形消退并成功妊娠
Obstet Gynecol. 2011 Feb;117(2 Pt 2):452-455. doi: 10.1097/AOG.0b013e3181f7381f.
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Embolization of uterine arteriovenous malformations associated with cyanotic congenital heart disease.与青紫型先天性心脏病相关的子宫动静脉畸形的栓塞治疗
Cardiovasc Intervent Radiol. 2009 Sep;32(5):1075-9. doi: 10.1007/s00270-009-9573-z. Epub 2009 May 7.
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Uterine arteriovenous malformations: a review of the current literature.子宫动静脉畸形：当前文献综述
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Endothelial expression of constitutively active Notch4 elicits reversible arteriovenous malformations in adult mice.组成型活性Notch4的内皮表达在成年小鼠中引发可逆性动静脉畸形。
Proc Natl Acad Sci U S A. 2005 Jul 12;102(28):9884-9. doi: 10.1073/pnas.0504391102. Epub 2005 Jun 30.
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Immunohistochemistry of vascular changes in leuprolide acetate-treated leiomyomas.醋酸亮丙瑞林治疗的平滑肌瘤血管变化的免疫组织化学研究
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