Li R Z, He Y Q, Chiao M, Xu Y, Zhang Q B, Meng J R, Gu Y, Ge L P
Yao Xue Xue Bao. 1989;24(7):546-51.
Eight coumarins isolated from the alcohol extract of the Chinese drug "Duhuo", the root of Angelica pubescents Maxim. f. biserrata Shan et Yuan (Umbelliferae) were elucidated to be columbianetin (I), columbianetin acetate (II), columbiadin (III), osthol (IV), isoimperatorin (V), bergapten (VI), xanthotoxin (VII), and columbianetin-beta-D-glucopyranoside (VIII), by chemical and spectral analysis, compound VIII was isolated from plant for the first time. All these coumarins were tested on platelet aggregation induced by 2 microns ADP. I, II, III, IV and VIII showed strong inhibiting activity against platelet aggregation.
从中药材“独活”（伞形科植物毛当归Angelica pubescents Maxim. f. biserrata Shan et Yuan的根）的乙醇提取物中分离得到8种香豆素，通过化学和光谱分析确定它们分别为：哥伦比亚内酯（I）、哥伦比亚内酯乙酸酯（II）、哥伦比亚苷（III）、蛇床子素（IV）、异欧前胡素（V）、佛手柑内酯（VI）、花椒毒素（VII）和哥伦比亚内酯-β-D-葡萄糖苷（VIII），化合物VIII为首次从该植物中分离得到。所有这些香豆素均针对2微米ADP诱导的血小板聚集进行了测试。I、II、III、IV和VIII对血小板聚集表现出较强的抑制活性。
